Advanced

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

Chen, Kang; Xu, Weifeng; Wilson, Melanie; He, Bing; Miller, Norman W.; Bengten, Eva; Edholm, Eva-Stina; Santini, Paul A.; Rath, Poonam and Chiu, April, et al. (2009) In Nature Immunology 10(8). p.121-889
Abstract
Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD... (More)
Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Immunology
volume
10
issue
8
pages
121 - 889
publisher
Nature Publishing Group
external identifiers
  • wos:000268141400019
  • scopus:67651147945
ISSN
1529-2908
DOI
10.1038/ni.1748
language
English
LU publication?
yes
id
9827d555-9fe0-4af3-aba4-f0b42718d772 (old id 1461428)
date added to LUP
2009-08-31 10:41:33
date last changed
2017-12-10 03:56:56
@article{9827d555-9fe0-4af3-aba4-f0b42718d772,
  abstract     = {Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.},
  author       = {Chen, Kang and Xu, Weifeng and Wilson, Melanie and He, Bing and Miller, Norman W. and Bengten, Eva and Edholm, Eva-Stina and Santini, Paul A. and Rath, Poonam and Chiu, April and Cattalini, Marco and Litzman, Jiri and Bussel, James B. and Huang, Bihui and Meini, Antonella and Riesbeck, Kristian and Cunningham-Rundles, Charlotte and Plebani, Alessandro and Cerutti, Andrea},
  issn         = {1529-2908},
  language     = {eng},
  number       = {8},
  pages        = {121--889},
  publisher    = {Nature Publishing Group},
  series       = {Nature Immunology},
  title        = {Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils},
  url          = {http://dx.doi.org/10.1038/ni.1748},
  volume       = {10},
  year         = {2009},
}