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A Variation in the Cerebroside Sulfotransferase Gene Is Linked to Exercise-Modified Insulin Resistance and to Type 2 Diabetes

Roeske-Nielsen, A. ; Buschard, K. ; Manson, J. E. ; Råstam, Lennart LU and Lindblad, Ulf LU (2009) In Experimental Diabetes Research
Abstract
Aims. The glycosphingolipid beta-galactosylceramide-3-O-sulfate (sulfatide) is present in the secretory granules of the insulin producing beta-cells and may act as a molecular chaperone of insulin. The final step in sulfatide synthesis is performed by cerebroside sulfotransferase (CST) (EC 2.8.2.11). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNP), rs2267161 located in an exon or rs42929 located in an intron, in the gene encoding CST are linked to type 2 diabetes (T2D). Methods. As a population survey, 265 male and female patients suffering from T2D and 291 gender matched controls were examined. Results. A higher proportion of T2D patients were heterozygous at SNP rs2267161 with both T... (More)
Aims. The glycosphingolipid beta-galactosylceramide-3-O-sulfate (sulfatide) is present in the secretory granules of the insulin producing beta-cells and may act as a molecular chaperone of insulin. The final step in sulfatide synthesis is performed by cerebroside sulfotransferase (CST) (EC 2.8.2.11). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNP), rs2267161 located in an exon or rs42929 located in an intron, in the gene encoding CST are linked to type 2 diabetes (T2D). Methods. As a population survey, 265 male and female patients suffering from T2D and 291 gender matched controls were examined. Results. A higher proportion of T2D patients were heterozygous at SNP rs2267161 with both T (methionine) and C (valine) alleles present (49.8% versus 41.3%, P = .04). The calculated odd risk for T2D was 1.47 (1.01-2.15, P = .047). Among female controls, the homozygous CC individuals displayed lower insulin resistance measured by HOMA-IR (P = .05) than the C/T or TT persons; this was particularly prevalent in individuals who exercise (P = .03). Conclusion. Heterozygosity at SNP rs2267161 in the gene encoding the CST enzyme confers increased risk of T2D. Females with the CC allele showed lower insulin resistance. Copyright (C) 2009 A. Roeske-Nielsen et al. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Diabetes Research
article number
429593
publisher
Hindawi Limited
external identifiers
  • wos:000268092600001
  • scopus:69449096714
ISSN
1687-5214
DOI
10.1155/2009/429593
language
English
LU publication?
yes
id
b22284c7-1b76-45c9-9f28-250db8daf41d (old id 1461658)
date added to LUP
2016-04-01 12:03:52
date last changed
2022-01-26 22:18:26
@article{b22284c7-1b76-45c9-9f28-250db8daf41d,
  abstract     = {{Aims. The glycosphingolipid beta-galactosylceramide-3-O-sulfate (sulfatide) is present in the secretory granules of the insulin producing beta-cells and may act as a molecular chaperone of insulin. The final step in sulfatide synthesis is performed by cerebroside sulfotransferase (CST) (EC 2.8.2.11). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNP), rs2267161 located in an exon or rs42929 located in an intron, in the gene encoding CST are linked to type 2 diabetes (T2D). Methods. As a population survey, 265 male and female patients suffering from T2D and 291 gender matched controls were examined. Results. A higher proportion of T2D patients were heterozygous at SNP rs2267161 with both T (methionine) and C (valine) alleles present (49.8% versus 41.3%, P = .04). The calculated odd risk for T2D was 1.47 (1.01-2.15, P = .047). Among female controls, the homozygous CC individuals displayed lower insulin resistance measured by HOMA-IR (P = .05) than the C/T or TT persons; this was particularly prevalent in individuals who exercise (P = .03). Conclusion. Heterozygosity at SNP rs2267161 in the gene encoding the CST enzyme confers increased risk of T2D. Females with the CC allele showed lower insulin resistance. Copyright (C) 2009 A. Roeske-Nielsen et al.}},
  author       = {{Roeske-Nielsen, A. and Buschard, K. and Manson, J. E. and Råstam, Lennart and Lindblad, Ulf}},
  issn         = {{1687-5214}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{Experimental Diabetes Research}},
  title        = {{A Variation in the Cerebroside Sulfotransferase Gene Is Linked to Exercise-Modified Insulin Resistance and to Type 2 Diabetes}},
  url          = {{http://dx.doi.org/10.1155/2009/429593}},
  doi          = {{10.1155/2009/429593}},
  year         = {{2009}},
}