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Cardiac Structure and Function Before and After Parathyroidectomy in Patients With Asymptomatic Primary Hyperparathyroidism

Birgander, Mats ; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Willenheimer, Ronnie LU and Rydberg, Erik LU (2009) In The Endocrinologist 19(4). p.154-158
Abstract
Background: Primary hyperparathyroidism (PHPT) is associated with cardiac disease and increased risk of all-cause and cardiovascular mortality. We investigated cardiac structural and functional parameters before and after successful parathyroidectomy in asymptomatic PHPT patients. Methods and Results: Forty-nine PHPT patients (age: 62.9 +/- 11 years, 5 men) and 48 healthy control subjects, matched for age, sex and smoking status were enrolled in the study. PHPT patients were examined preoperatively and 6 and 12 months postoperatively. Structural and functional cardiac parameters were assessed by transthoracic echocardiography. One year after parathyroidectomy left ventricular (LV) mass, left atrial size, LV enddiastolic and endsystolic... (More)
Background: Primary hyperparathyroidism (PHPT) is associated with cardiac disease and increased risk of all-cause and cardiovascular mortality. We investigated cardiac structural and functional parameters before and after successful parathyroidectomy in asymptomatic PHPT patients. Methods and Results: Forty-nine PHPT patients (age: 62.9 +/- 11 years, 5 men) and 48 healthy control subjects, matched for age, sex and smoking status were enrolled in the study. PHPT patients were examined preoperatively and 6 and 12 months postoperatively. Structural and functional cardiac parameters were assessed by transthoracic echocardiography. One year after parathyroidectomy left ventricular (LV) mass, left atrial size, LV enddiastolic and endsystolic diameters, LV posterior wall and interventricular septum diameter, and right ventricular enddiastolic diameter were all increased in PHPT patients, although not significantly. As an indication of worsened LV diastolic function, the heart rate adjusted Doppler-derived deceleration time of the transmittal E-wave increased among PHPT patients (276 +/- 82-303 +/- 54 milliseconds, P = 0.004). There was also deterioration of LV ejection fraction (from 62.7 +/- 7 to 59.9 +/- 7.8%, P = 0.868) and mean atrioventricular plane displacement (from 13.2 +/- 2 to 12.6 +/- 2 mm, P = 0.029). Conclusion: There were no significant differences in heart function between hyperparathyroid and control subjects, and 6 months after parathyroidectomy, there was no change in heart function in hyperparathyroid subjects. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
primary, surgery, myocardium, echocardiography, heart failure, hyperthyroidism
in
The Endocrinologist
volume
19
issue
4
pages
154 - 158
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000268054600002
  • scopus:68849083226
ISSN
1539-9192
DOI
10.1097/TEN.0b013e3181acb1ab
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardiology Research Group (013242120), Pathology (Malmö) (013031000), Emergency medicine/Medicine/Surgery (013240200)
id
15ab6a0c-3685-43d9-b439-4eba5b4367fe (old id 1461705)
date added to LUP
2016-04-01 12:01:26
date last changed
2022-01-26 21:39:40
@article{15ab6a0c-3685-43d9-b439-4eba5b4367fe,
  abstract     = {{Background: Primary hyperparathyroidism (PHPT) is associated with cardiac disease and increased risk of all-cause and cardiovascular mortality. We investigated cardiac structural and functional parameters before and after successful parathyroidectomy in asymptomatic PHPT patients. Methods and Results: Forty-nine PHPT patients (age: 62.9 +/- 11 years, 5 men) and 48 healthy control subjects, matched for age, sex and smoking status were enrolled in the study. PHPT patients were examined preoperatively and 6 and 12 months postoperatively. Structural and functional cardiac parameters were assessed by transthoracic echocardiography. One year after parathyroidectomy left ventricular (LV) mass, left atrial size, LV enddiastolic and endsystolic diameters, LV posterior wall and interventricular septum diameter, and right ventricular enddiastolic diameter were all increased in PHPT patients, although not significantly. As an indication of worsened LV diastolic function, the heart rate adjusted Doppler-derived deceleration time of the transmittal E-wave increased among PHPT patients (276 +/- 82-303 +/- 54 milliseconds, P = 0.004). There was also deterioration of LV ejection fraction (from 62.7 +/- 7 to 59.9 +/- 7.8%, P = 0.868) and mean atrioventricular plane displacement (from 13.2 +/- 2 to 12.6 +/- 2 mm, P = 0.029). Conclusion: There were no significant differences in heart function between hyperparathyroid and control subjects, and 6 months after parathyroidectomy, there was no change in heart function in hyperparathyroid subjects.}},
  author       = {{Birgander, Mats and Bondeson, Anne-Greth and Bondeson, Lennart and Willenheimer, Ronnie and Rydberg, Erik}},
  issn         = {{1539-9192}},
  keywords     = {{primary; surgery; myocardium; echocardiography; heart failure; hyperthyroidism}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{154--158}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{The Endocrinologist}},
  title        = {{Cardiac Structure and Function Before and After Parathyroidectomy in Patients With Asymptomatic Primary Hyperparathyroidism}},
  url          = {{http://dx.doi.org/10.1097/TEN.0b013e3181acb1ab}},
  doi          = {{10.1097/TEN.0b013e3181acb1ab}},
  volume       = {{19}},
  year         = {{2009}},
}