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Fluorescence diffuse optical tomography using upconverting nanoparticles

Xu, Can LU ; Axelsson, Johan LU and Andersson-Engels, Stefan LU (2009) In Applied Physics Letters 94(25).
Abstract
Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sodium compounds, photoluminescence, phantoms, optical tomography, nanoparticles, nanobiotechnology, biological tissues, fluorescence, thulium, ytterbium, yttrium compounds
in
Applied Physics Letters
volume
94
issue
25
publisher
American Institute of Physics
external identifiers
  • wos:000267431700007
  • scopus:67649482458
ISSN
0003-6951
DOI
10.1063/1.3156857
language
English
LU publication?
yes
id
ad087763-96df-4889-8fd5-2e6f2abeb06e (old id 1463482)
date added to LUP
2009-08-18 10:03:30
date last changed
2017-07-23 03:36:12
@article{ad087763-96df-4889-8fd5-2e6f2abeb06e,
  abstract     = {Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.},
  author       = {Xu, Can and Axelsson, Johan and Andersson-Engels, Stefan},
  issn         = {0003-6951},
  keyword      = {sodium compounds,photoluminescence,phantoms,optical tomography,nanoparticles,nanobiotechnology,biological tissues,fluorescence,thulium,ytterbium,yttrium compounds},
  language     = {eng},
  number       = {25},
  publisher    = {American Institute of Physics},
  series       = {Applied Physics Letters},
  title        = {Fluorescence diffuse optical tomography using upconverting nanoparticles},
  url          = {http://dx.doi.org/10.1063/1.3156857},
  volume       = {94},
  year         = {2009},
}