Fluorescence diffuse optical tomography using upconverting nanoparticles
(2009) In Applied Physics Letters 94(25).- Abstract
- Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1463482
- author
- Xu, Can LU ; Axelsson, Johan LU and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sodium compounds, photoluminescence, phantoms, optical tomography, nanoparticles, nanobiotechnology, biological tissues, fluorescence, thulium, ytterbium, yttrium compounds
- in
- Applied Physics Letters
- volume
- 94
- issue
- 25
- publisher
- American Institute of Physics (AIP)
- external identifiers
-
- wos:000267431700007
- scopus:67649482458
- ISSN
- 0003-6951
- DOI
- 10.1063/1.3156857
- language
- English
- LU publication?
- yes
- id
- ad087763-96df-4889-8fd5-2e6f2abeb06e (old id 1463482)
- date added to LUP
- 2016-04-01 11:38:44
- date last changed
- 2022-01-26 08:05:35
@article{ad087763-96df-4889-8fd5-2e6f2abeb06e, abstract = {{Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.}}, author = {{Xu, Can and Axelsson, Johan and Andersson-Engels, Stefan}}, issn = {{0003-6951}}, keywords = {{sodium compounds; photoluminescence; phantoms; optical tomography; nanoparticles; nanobiotechnology; biological tissues; fluorescence; thulium; ytterbium; yttrium compounds}}, language = {{eng}}, number = {{25}}, publisher = {{American Institute of Physics (AIP)}}, series = {{Applied Physics Letters}}, title = {{Fluorescence diffuse optical tomography using upconverting nanoparticles}}, url = {{https://lup.lub.lu.se/search/files/2576122/2370939.pdf}}, doi = {{10.1063/1.3156857}}, volume = {{94}}, year = {{2009}}, }