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Uric Acid Levels Have No Significant Effect on Renal Function in Adult Renal Transplant Recipients: Evidence from the Symphony Study.

Meier-Kriesche, Herwig-Ulf; Schold, Jesse D; Vanrenterghem, Yves; Halloran, Philip F and Ekberg, Henrik LU (2009) In Clinical Journal of the American Society of Nephrology 4. p.1655-1660
Abstract
BACKGROUND AND OBJECTIVES: Uric acid (UA) has been linked to renal damage in experimental models of kidney failure. In humans, no definitive link between UA and renal function has been established, but several epidemiologic studies have suggested that higher UA levels are associated with accelerated loss of renal function, higher incidence of dialysis, and death. Many of the associations have been limited by the colinearity between UA levels and renal function. Renal transplantation is no exception, and limited information is available concerning the independent role of UA on progression of renal function in transplant recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We investigated the association between UA and renal... (More)
BACKGROUND AND OBJECTIVES: Uric acid (UA) has been linked to renal damage in experimental models of kidney failure. In humans, no definitive link between UA and renal function has been established, but several epidemiologic studies have suggested that higher UA levels are associated with accelerated loss of renal function, higher incidence of dialysis, and death. Many of the associations have been limited by the colinearity between UA levels and renal function. Renal transplantation is no exception, and limited information is available concerning the independent role of UA on progression of renal function in transplant recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We investigated the association between UA and renal function progression during the first 3 yr after transplantation, adjusted for baseline renal function, in 1645 patients who were enrolled in the Symphony study. RESULTS: When corrected for baseline renal function, UA levels 1 mo after transplantation were not associated with 3-yr renal function (P = 0.62). There was a strong colinearity between calculated renal function and UA levels 1 mo after transplantation. In fact, when not corrected for baseline renal function, there was a significant association between UA and renal function at 3 yr (P = 0.005). CONCLUSIONS: Low renal function is associated with higher UA levels, but higher UA levels are not independently associated with progression of renal dysfunction after kidney transplantation. (Less)
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type
Contribution to journal
publication status
published
subject
in
Clinical Journal of the American Society of Nephrology
volume
4
pages
1655 - 1660
publisher
Amer Soc Nephrology
external identifiers
  • wos:000270617900017
  • pmid:19713295
  • scopus:73349142001
ISSN
1555-905X
DOI
10.2215/CJN.02700409
language
English
LU publication?
yes
id
46699ca8-386e-4302-b5e1-276a30918849 (old id 1469261)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19713295?dopt=Abstract
date added to LUP
2009-09-07 10:29:27
date last changed
2017-12-10 04:40:56
@article{46699ca8-386e-4302-b5e1-276a30918849,
  abstract     = {BACKGROUND AND OBJECTIVES: Uric acid (UA) has been linked to renal damage in experimental models of kidney failure. In humans, no definitive link between UA and renal function has been established, but several epidemiologic studies have suggested that higher UA levels are associated with accelerated loss of renal function, higher incidence of dialysis, and death. Many of the associations have been limited by the colinearity between UA levels and renal function. Renal transplantation is no exception, and limited information is available concerning the independent role of UA on progression of renal function in transplant recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We investigated the association between UA and renal function progression during the first 3 yr after transplantation, adjusted for baseline renal function, in 1645 patients who were enrolled in the Symphony study. RESULTS: When corrected for baseline renal function, UA levels 1 mo after transplantation were not associated with 3-yr renal function (P = 0.62). There was a strong colinearity between calculated renal function and UA levels 1 mo after transplantation. In fact, when not corrected for baseline renal function, there was a significant association between UA and renal function at 3 yr (P = 0.005). CONCLUSIONS: Low renal function is associated with higher UA levels, but higher UA levels are not independently associated with progression of renal dysfunction after kidney transplantation.},
  author       = {Meier-Kriesche, Herwig-Ulf and Schold, Jesse D and Vanrenterghem, Yves and Halloran, Philip F and Ekberg, Henrik},
  issn         = {1555-905X},
  language     = {eng},
  pages        = {1655--1660},
  publisher    = {Amer Soc Nephrology},
  series       = {Clinical Journal of the American Society of Nephrology},
  title        = {Uric Acid Levels Have No Significant Effect on Renal Function in Adult Renal Transplant Recipients: Evidence from the Symphony Study.},
  url          = {http://dx.doi.org/10.2215/CJN.02700409},
  volume       = {4},
  year         = {2009},
}