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Mannose-binding lectin as a risk factor for acute coronary syndromes.

Pesonen, Erkki LU ; Hallman, Mikko; Sarna, Seppo; Andsberg, Eva; Haataja, Ritva; Meri, Seppo; Persson, Kenneth LU ; Puolakkainen, Mirja; Öhlin, Hans LU and Truedsson, Lennart LU (2009) In Annals of Medicine 41. p.591-598
Abstract
Background. Mannose-binding lectin (MBL) is a multifunctional protein involved in innate immunity. We tested whether MBL and elevated viral and bacterial antibodies were risk factors for acute coronary events. Design. Controlled cohort study. Methods. A total of 354 patients with unstable angina pectoris (UA) or acute myocardial infarction (AMI) were compared with 334 paired controls. Results. Enterovirus titres were associated with increased risk of UA (odds ratio 10.04, P<0.001) and AMI (odds ratio 3.18, P=0.003), but titres did not correlate with either MBL concentration or genotype. Chlamydia pneumoniae heat shock protein 60 IgG concentrations were also associated with increased risk of UA (odds ratio 1.63, P=0.049). Compared to... (More)
Background. Mannose-binding lectin (MBL) is a multifunctional protein involved in innate immunity. We tested whether MBL and elevated viral and bacterial antibodies were risk factors for acute coronary events. Design. Controlled cohort study. Methods. A total of 354 patients with unstable angina pectoris (UA) or acute myocardial infarction (AMI) were compared with 334 paired controls. Results. Enterovirus titres were associated with increased risk of UA (odds ratio 10.04, P<0.001) and AMI (odds ratio 3.18, P=0.003), but titres did not correlate with either MBL concentration or genotype. Chlamydia pneumoniae heat shock protein 60 IgG concentrations were also associated with increased risk of UA (odds ratio 1.63, P=0.049). Compared to asymptomatic controls, patients had lower complement C3 serum concentrations (P<0.001), higher MBL serum concentration, and more frequently had MBL genotypes that determined high MBL levels (P<0.001). High MBL genotypes had odds ratios of 1.16 (P=0.010) for UA and 1.12 (P=0.007) for AMI. The elevation of MBL concentrations in the acute phase correlated with MBL concentrations after recovery (r=0.85, P<0.001). Conclusions. Elevated microbial titres, indicating an on-going inflammation, were associated with cardiovascular events. MBL might have a dual role both decreasing susceptibility to infections and increasing the risk of acute coronary syndromes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Medicine
volume
41
pages
591 - 598
publisher
Informa Healthcare
external identifiers
  • wos:000271608200004
  • pmid:19711212
  • scopus:72949119387
ISSN
1365-2060
DOI
10.1080/07853890903110994
language
English
LU publication?
yes
id
853d71d5-d684-4bd2-99fa-8fe05f5fdc7e (old id 1469269)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19711212?dopt=Abstract
date added to LUP
2009-09-07 15:34:48
date last changed
2017-10-08 04:29:54
@article{853d71d5-d684-4bd2-99fa-8fe05f5fdc7e,
  abstract     = {Background. Mannose-binding lectin (MBL) is a multifunctional protein involved in innate immunity. We tested whether MBL and elevated viral and bacterial antibodies were risk factors for acute coronary events. Design. Controlled cohort study. Methods. A total of 354 patients with unstable angina pectoris (UA) or acute myocardial infarction (AMI) were compared with 334 paired controls. Results. Enterovirus titres were associated with increased risk of UA (odds ratio 10.04, P&lt;0.001) and AMI (odds ratio 3.18, P=0.003), but titres did not correlate with either MBL concentration or genotype. Chlamydia pneumoniae heat shock protein 60 IgG concentrations were also associated with increased risk of UA (odds ratio 1.63, P=0.049). Compared to asymptomatic controls, patients had lower complement C3 serum concentrations (P&lt;0.001), higher MBL serum concentration, and more frequently had MBL genotypes that determined high MBL levels (P&lt;0.001). High MBL genotypes had odds ratios of 1.16 (P=0.010) for UA and 1.12 (P=0.007) for AMI. The elevation of MBL concentrations in the acute phase correlated with MBL concentrations after recovery (r=0.85, P&lt;0.001). Conclusions. Elevated microbial titres, indicating an on-going inflammation, were associated with cardiovascular events. MBL might have a dual role both decreasing susceptibility to infections and increasing the risk of acute coronary syndromes.},
  author       = {Pesonen, Erkki and Hallman, Mikko and Sarna, Seppo and Andsberg, Eva and Haataja, Ritva and Meri, Seppo and Persson, Kenneth and Puolakkainen, Mirja and Öhlin, Hans and Truedsson, Lennart},
  issn         = {1365-2060},
  language     = {eng},
  pages        = {591--598},
  publisher    = {Informa Healthcare},
  series       = {Annals of Medicine},
  title        = {Mannose-binding lectin as a risk factor for acute coronary syndromes.},
  url          = {http://dx.doi.org/10.1080/07853890903110994},
  volume       = {41},
  year         = {2009},
}