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Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.

Diffner, Eva LU ; Gauffin, Fredrika; Anagnostaki, Lola; Nordgren, Ann; Gustafsson, Bertil; Sander, Birgitta; Gustafsson, Britt and Persson, Jenny L LU (2009) In Journal of Pediatric Hematology/Oncology1995-01-01+01:00 31. p.696-701
Abstract
Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood... (More)
Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pediatric Hematology/Oncology1995-01-01+01:00
volume
31
pages
696 - 701
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000269701800018
  • pmid:19707156
  • scopus:70349113909
ISSN
1536-3678
DOI
10.1097/MPH.0b013e3181b258df
language
English
LU publication?
yes
id
0b28e023-d1b6-4d50-ae31-da57c2f8d0e9 (old id 1469324)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19707156?dopt=Abstract
date added to LUP
2009-09-07 15:43:05
date last changed
2017-08-13 04:34:59
@article{0b28e023-d1b6-4d50-ae31-da57c2f8d0e9,
  abstract     = {Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.},
  author       = {Diffner, Eva and Gauffin, Fredrika and Anagnostaki, Lola and Nordgren, Ann and Gustafsson, Bertil and Sander, Birgitta and Gustafsson, Britt and Persson, Jenny L},
  issn         = {1536-3678},
  language     = {eng},
  pages        = {696--701},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Pediatric Hematology/Oncology1995-01-01+01:00},
  title        = {Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.},
  url          = {http://dx.doi.org/10.1097/MPH.0b013e3181b258df},
  volume       = {31},
  year         = {2009},
}