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Tipping the balance of deterministic lateral displacement devices using dielectrophoresis.

Beech, Jason LU ; Jönsson, Peter LU and Tegenfeldt, Jonas LU (2009) In Lab on A Chip 9(18). p.2698-2706
Abstract
We report the use of dielectrophoresis (DEP) to achieve tunability, improve dynamic range and open up for the separation of particles with regard to parameters other than hydrodynamic size in deterministic lateral displacement (DLD) devices. DLD devices have been shown capable of rapidly and continuously separating micrometer sized plastic spheres by size with a resolution of 20 nm in diameter and of being able to handle the separation of biological samples as wide ranging as bacterial artificial chromosomes and blood cells. DEP, while not exhibiting the same resolution in size separation as DLD, has the benefit of being easy to tune and can, by choosing the frequency, be used to probe a variety of particle properties. By combining DLD and... (More)
We report the use of dielectrophoresis (DEP) to achieve tunability, improve dynamic range and open up for the separation of particles with regard to parameters other than hydrodynamic size in deterministic lateral displacement (DLD) devices. DLD devices have been shown capable of rapidly and continuously separating micrometer sized plastic spheres by size with a resolution of 20 nm in diameter and of being able to handle the separation of biological samples as wide ranging as bacterial artificial chromosomes and blood cells. DEP, while not exhibiting the same resolution in size separation as DLD, has the benefit of being easy to tune and can, by choosing the frequency, be used to probe a variety of particle properties. By combining DLD and DEP we open up for the advantages, while avoiding the drawbacks, of the two techniques. We present a proof of principle in which the critical size for separation of polystyrene beads is tuned in the range 2-6 microm in a single device by the application of moderate (100 V cm(-1)), low frequency (100 Hz) AC electric fields. The behaviour of the device was further investigated by performing simulations of particle trajectories, the results of which were in good qualitative agreement with experiments, indicating the potential of the method for tunable, high-resolution separations with respect to both size and polarisability. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lab on A Chip
volume
9
issue
18
pages
2698 - 2706
publisher
Royal Society of Chemistry
external identifiers
  • wos:000269289600012
  • pmid:19704986
  • scopus:69549121516
ISSN
1473-0189
DOI
10.1039/b823275j
language
English
LU publication?
yes
id
8628f047-28a1-42cd-bec5-b7e847de2829 (old id 1469393)
date added to LUP
2009-09-11 12:19:38
date last changed
2017-11-05 03:38:17
@article{8628f047-28a1-42cd-bec5-b7e847de2829,
  abstract     = {We report the use of dielectrophoresis (DEP) to achieve tunability, improve dynamic range and open up for the separation of particles with regard to parameters other than hydrodynamic size in deterministic lateral displacement (DLD) devices. DLD devices have been shown capable of rapidly and continuously separating micrometer sized plastic spheres by size with a resolution of 20 nm in diameter and of being able to handle the separation of biological samples as wide ranging as bacterial artificial chromosomes and blood cells. DEP, while not exhibiting the same resolution in size separation as DLD, has the benefit of being easy to tune and can, by choosing the frequency, be used to probe a variety of particle properties. By combining DLD and DEP we open up for the advantages, while avoiding the drawbacks, of the two techniques. We present a proof of principle in which the critical size for separation of polystyrene beads is tuned in the range 2-6 microm in a single device by the application of moderate (100 V cm(-1)), low frequency (100 Hz) AC electric fields. The behaviour of the device was further investigated by performing simulations of particle trajectories, the results of which were in good qualitative agreement with experiments, indicating the potential of the method for tunable, high-resolution separations with respect to both size and polarisability.},
  author       = {Beech, Jason and Jönsson, Peter and Tegenfeldt, Jonas},
  issn         = {1473-0189},
  language     = {eng},
  number       = {18},
  pages        = {2698--2706},
  publisher    = {Royal Society of Chemistry},
  series       = {Lab on A Chip},
  title        = {Tipping the balance of deterministic lateral displacement devices using dielectrophoresis.},
  url          = {http://dx.doi.org/10.1039/b823275j},
  volume       = {9},
  year         = {2009},
}