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Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.

Ekman, Carl LU ; Flondell-Sité, Despina LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU (2010) In Clinical Biochemistry 43. p.110-114
Abstract
OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients... (More)
OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients with a large AAA had higher Gas6/sAxl ratio than any in the control group. DISCUSSION: The Gas6/Axl system might be involved in AAA pathogenesis, and the Gas6/sAxl ratio may be useful as a biomarker. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
43
pages
110 - 114
publisher
Elsevier
external identifiers
  • wos:000273514400016
  • pmid:19660445
  • scopus:73049088895
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2009.07.025
language
English
LU publication?
yes
id
f39f2724-2213-4176-805f-35bf63bb15a9 (old id 1469947)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19660445?dopt=Abstract
date added to LUP
2009-09-04 14:47:07
date last changed
2018-05-29 11:28:11
@article{f39f2724-2213-4176-805f-35bf63bb15a9,
  abstract     = {OBJECTIVE: The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers. DESIGN AND METHODS: Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141). RESULTS: Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients with a large AAA had higher Gas6/sAxl ratio than any in the control group. DISCUSSION: The Gas6/Axl system might be involved in AAA pathogenesis, and the Gas6/sAxl ratio may be useful as a biomarker.},
  author       = {Ekman, Carl and Flondell-Sité, Despina and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn},
  issn         = {1873-2933},
  language     = {eng},
  pages        = {110--114},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2009.07.025},
  volume       = {43},
  year         = {2010},
}