Reduced myelinated nerve fibre and endoneurial capillary densities in the forearm of diabetic and non-diabetic patients with carpal tunnel syndrome.
Thomsen, Niels LU ; Mojaddidi, Moaz ; Malik, Rayaz and Dahlin, Lars LU
(2009)
In Acta Neuropathologica
118.
p.785-791
- Abstract
- The underlying basis of carpal tunnel syndrome (CTS) and the basis of its increased incidence in diabetes are unknown. We have quantified pathology in an uncompressed nerve (posterior interosseous nerve, PIN) in the forearm between diabetic and non-diabetic patients with CTS and control subjects. In an age- and gender-matched series, 26 diabetic patients with CTS and 20 non-diabetic patients with CTS underwent biopsy of the PIN at the time of surgical carpal tunnel release. Control subjects consisted of ten PIN biopsies taken postmortem and three biopsies taken at the time of wrist surgery. We found PIN myelinated nerve fibre density significantly reduced in diabetic (mean 5,373/mm(2) [95% confidence interval, 4,835-5,911]) and... (More)
- The underlying basis of carpal tunnel syndrome (CTS) and the basis of its increased incidence in diabetes are unknown. We have quantified pathology in an uncompressed nerve (posterior interosseous nerve, PIN) in the forearm between diabetic and non-diabetic patients with CTS and control subjects. In an age- and gender-matched series, 26 diabetic patients with CTS and 20 non-diabetic patients with CTS underwent biopsy of the PIN at the time of surgical carpal tunnel release. Control subjects consisted of ten PIN biopsies taken postmortem and three biopsies taken at the time of wrist surgery. We found PIN myelinated nerve fibre density significantly reduced in diabetic (mean 5,373/mm(2) [95% confidence interval, 4,835-5,911]) and non-diabetic (6,617/mm(2) [5,697-7,537]) patients with CTS compared to control subjects (9,109/mm(2) [7,967-10,250], P < 0.001). Furthermore, diabetic patients had a significantly lower density than non-diabetic patients (P < 0.03). Endoneurial capillary density was also reduced in diabetic (58/mm(2) [50-66]) and non-diabetic (67/mm(2) [55-78]) patients compared to control subjects (86/mm(2) [72-101], P < 0.02) with no difference between diabetic and non-diabetic patients with CTS. Our results suggest that a reduction in myelinated nerve fibre and capillary densities may predispose patients, particularly those with diabetes, to develop CTS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1470225
- author
- Thomsen, Niels
LU
; Mojaddidi, Moaz
; Malik, Rayaz
and Dahlin, Lars
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Neuropathologica
- volume
- 118
- pages
- 785 - 791
- publisher
- Springer
- external identifiers
-
- wos:000271808600007
- pmid:19641929
- scopus:71449119702
- ISSN
- 1432-0533
- DOI
- 10.1007/s00401-009-0578-0
- project
- Diabetic neuropathy and nerve compression in diabetes
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Hand Surgery Research Group (013241910)
- id
- a5de77fb-ea05-4d8d-aea1-018979a22cc2 (old id 1470225)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19641929?dopt=Abstract
- date added to LUP
- 2016-04-04 09:20:26
- date last changed
- 2022-04-23 20:02:32
@article{a5de77fb-ea05-4d8d-aea1-018979a22cc2,
abstract = {{The underlying basis of carpal tunnel syndrome (CTS) and the basis of its increased incidence in diabetes are unknown. We have quantified pathology in an uncompressed nerve (posterior interosseous nerve, PIN) in the forearm between diabetic and non-diabetic patients with CTS and control subjects. In an age- and gender-matched series, 26 diabetic patients with CTS and 20 non-diabetic patients with CTS underwent biopsy of the PIN at the time of surgical carpal tunnel release. Control subjects consisted of ten PIN biopsies taken postmortem and three biopsies taken at the time of wrist surgery. We found PIN myelinated nerve fibre density significantly reduced in diabetic (mean 5,373/mm(2) [95% confidence interval, 4,835-5,911]) and non-diabetic (6,617/mm(2) [5,697-7,537]) patients with CTS compared to control subjects (9,109/mm(2) [7,967-10,250], P < 0.001). Furthermore, diabetic patients had a significantly lower density than non-diabetic patients (P < 0.03). Endoneurial capillary density was also reduced in diabetic (58/mm(2) [50-66]) and non-diabetic (67/mm(2) [55-78]) patients compared to control subjects (86/mm(2) [72-101], P < 0.02) with no difference between diabetic and non-diabetic patients with CTS. Our results suggest that a reduction in myelinated nerve fibre and capillary densities may predispose patients, particularly those with diabetes, to develop CTS.}},
author = {{Thomsen, Niels and Mojaddidi, Moaz and Malik, Rayaz and Dahlin, Lars}},
issn = {{1432-0533}},
language = {{eng}},
pages = {{785--791}},
publisher = {{Springer}},
series = {{Acta Neuropathologica}},
title = {{Reduced myelinated nerve fibre and endoneurial capillary densities in the forearm of diabetic and non-diabetic patients with carpal tunnel syndrome.}},
url = {{http://dx.doi.org/10.1007/s00401-009-0578-0}},
doi = {{10.1007/s00401-009-0578-0}},
volume = {{118}},
year = {{2009}},
}