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Luminescence control in the marine bacterium Vibrio fischeri: An analysis of the dynamics of lux regulation

James, S; Nilsson, P; James, G; Kjelleberg, S and Fagerström, Torbjörn LU (2000) In Journal of Molecular Biology 296(4). p.1127-1137
Abstract
A mathematical model has been developed based on the fundamental properties of the control system formed by the lux genes and their products in Vibrio fischeri. The model Clearly demonstrates how the components of this system work together to create two, stable metabolic states corresponding to the expression of the luminescent and non-luminescent phenotypes. It is demonstrated how the cell can "switch" between these steady states due to changes in parameters describing metabolic processes and the extracellular concentration of the signal molecule N-3-oxohexanoyl-L-homoserine lactone. Ln addition, it is shown how these parameters influence how sensitive the switch mechanism is to cellular LuxR and N-3-oxohexanoyl-L-homoserine lactone and... (More)
A mathematical model has been developed based on the fundamental properties of the control system formed by the lux genes and their products in Vibrio fischeri. The model Clearly demonstrates how the components of this system work together to create two, stable metabolic states corresponding to the expression of the luminescent and non-luminescent phenotypes. It is demonstrated how the cell can "switch" between these steady states due to changes in parameters describing metabolic processes and the extracellular concentration of the signal molecule N-3-oxohexanoyl-L-homoserine lactone. Ln addition, it is shown how these parameters influence how sensitive the switch mechanism is to cellular LuxR and N-3-oxohexanoyl-L-homoserine lactone and complex concentration. While these properties could lead to the collective phenomenon known as quorum sensing, the model also predicts that under certain metabolic circumstances, basal expression of the lux genes could cause a cell to luminesce in the absence of extracellular signal molecule. Finally, the model developed in this study provides a basis for analysing the impact of other levels of control upon lux regulation. (C) 2000 Academic Press. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Molecular Biology
volume
296
issue
4
pages
1127 - 1137
publisher
Elsevier
external identifiers
  • scopus:0034598952
ISSN
1089-8638
DOI
10.1006/jmbi.1999.3484
language
English
LU publication?
yes
id
67882d7a-1c02-42ce-bc54-1cee13df6e5a (old id 147489)
date added to LUP
2007-07-03 12:10:29
date last changed
2017-07-02 04:21:22
@article{67882d7a-1c02-42ce-bc54-1cee13df6e5a,
  abstract     = {A mathematical model has been developed based on the fundamental properties of the control system formed by the lux genes and their products in Vibrio fischeri. The model Clearly demonstrates how the components of this system work together to create two, stable metabolic states corresponding to the expression of the luminescent and non-luminescent phenotypes. It is demonstrated how the cell can "switch" between these steady states due to changes in parameters describing metabolic processes and the extracellular concentration of the signal molecule N-3-oxohexanoyl-L-homoserine lactone. Ln addition, it is shown how these parameters influence how sensitive the switch mechanism is to cellular LuxR and N-3-oxohexanoyl-L-homoserine lactone and complex concentration. While these properties could lead to the collective phenomenon known as quorum sensing, the model also predicts that under certain metabolic circumstances, basal expression of the lux genes could cause a cell to luminesce in the absence of extracellular signal molecule. Finally, the model developed in this study provides a basis for analysing the impact of other levels of control upon lux regulation. (C) 2000 Academic Press.},
  author       = {James, S and Nilsson, P and James, G and Kjelleberg, S and Fagerström, Torbjörn},
  issn         = {1089-8638},
  language     = {eng},
  number       = {4},
  pages        = {1127--1137},
  publisher    = {Elsevier},
  series       = {Journal of Molecular Biology},
  title        = {Luminescence control in the marine bacterium Vibrio fischeri: An analysis of the dynamics of lux regulation},
  url          = {http://dx.doi.org/10.1006/jmbi.1999.3484},
  volume       = {296},
  year         = {2000},
}