Advanced

Prostate cancer as a first and second cancer: effect of family history

Zhang, H.; Bermejo, J. L.; Sundquist, Jan LU and Hemminki, K. (2009) In British Journal of Cancer 101(6). p.935-939
Abstract
BACKGROUND: Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far. METHODS: On the basis of the nationwide Swedish Family-Cancer Database including 18,207 primary invasive prostate cancers, standardised incidence ratios (SIRs) were used to estimate the relative risks of subsequent tumours after prostate cancer in the general population and among individuals with a parental history of cancer. RESULTS: A significantly increased SIR of colorectal cancer was found among prostate cancer patients with a parental history of colorectal cancer (2.26, 11 cases). The SIRs of parental concordant ( same site) tumours after... (More)
BACKGROUND: Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far. METHODS: On the basis of the nationwide Swedish Family-Cancer Database including 18,207 primary invasive prostate cancers, standardised incidence ratios (SIRs) were used to estimate the relative risks of subsequent tumours after prostate cancer in the general population and among individuals with a parental history of cancer. RESULTS: A significantly increased SIR of colorectal cancer was found among prostate cancer patients with a parental history of colorectal cancer (2.26, 11 cases). The SIRs of parental concordant ( same site) tumours after prostate cancer were also increased for urinary bladder cancer (4.42, 4 cases) and chronic lymphoid leukaemia (38.0, 2 cases). CONCLUSION: A higher than additive and multiplicative interaction was observed between the individual history of prostate cancer and parental history of colorectal and urinary bladder cancers, although the number of cases did not permit the rejection of any interaction model. The results suggest that the occurrence of second tumours, for example bladder after prostate or prostate after bladder tumours, is mostly related to shared genetic and non-genetic risk factors rather than treatment of first cancer. British Journal of Cancer ( 2009) 101, 935-939. doi:10.1038/sj.bjc.6605263 www.bjcancer.com Published online 18 August 2009 (C) 2009 Cancer Research UK (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
second primary malignancy, familial risk, prostate cancer
in
British Journal of Cancer
volume
101
issue
6
pages
935 - 939
publisher
Nature Publishing Group
external identifiers
  • wos:000269617200010
  • scopus:70249138661
ISSN
1532-1827
DOI
10.1038/sj.bjc.6605263
language
English
LU publication?
yes
id
f31c7528-a6ff-43b0-9268-a6052718b1d8 (old id 1475255)
date added to LUP
2009-10-02 09:36:11
date last changed
2017-05-28 03:40:41
@article{f31c7528-a6ff-43b0-9268-a6052718b1d8,
  abstract     = {BACKGROUND: Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far. METHODS: On the basis of the nationwide Swedish Family-Cancer Database including 18,207 primary invasive prostate cancers, standardised incidence ratios (SIRs) were used to estimate the relative risks of subsequent tumours after prostate cancer in the general population and among individuals with a parental history of cancer. RESULTS: A significantly increased SIR of colorectal cancer was found among prostate cancer patients with a parental history of colorectal cancer (2.26, 11 cases). The SIRs of parental concordant ( same site) tumours after prostate cancer were also increased for urinary bladder cancer (4.42, 4 cases) and chronic lymphoid leukaemia (38.0, 2 cases). CONCLUSION: A higher than additive and multiplicative interaction was observed between the individual history of prostate cancer and parental history of colorectal and urinary bladder cancers, although the number of cases did not permit the rejection of any interaction model. The results suggest that the occurrence of second tumours, for example bladder after prostate or prostate after bladder tumours, is mostly related to shared genetic and non-genetic risk factors rather than treatment of first cancer. British Journal of Cancer ( 2009) 101, 935-939. doi:10.1038/sj.bjc.6605263 www.bjcancer.com Published online 18 August 2009 (C) 2009 Cancer Research UK},
  author       = {Zhang, H. and Bermejo, J. L. and Sundquist, Jan and Hemminki, K.},
  issn         = {1532-1827},
  keyword      = {second primary malignancy,familial risk,prostate cancer},
  language     = {eng},
  number       = {6},
  pages        = {935--939},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Prostate cancer as a first and second cancer: effect of family history},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6605263},
  volume       = {101},
  year         = {2009},
}