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Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets

Korner, Anna; Piculell, Lennart LU ; Iselau, Frida; Wittgren, Bengt and Larsson, Anette (2009) In Molecules 14(8). p.2699-2716
Abstract
The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release... (More)
The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intrinsic viscosity, hydrophilic matrix tablets, release mechanism, PEO, HPMC, dextran
in
Molecules
volume
14
issue
8
pages
2699 - 2716
publisher
Molecular Diversity Preservation International
external identifiers
  • wos:000269196700002
  • scopus:69549137996
ISSN
1420-3049
DOI
10.3390/molecules14082699
language
English
LU publication?
yes
id
8ad5c3ed-52ad-41e1-b0ed-eed4e7d419a8 (old id 1476917)
date added to LUP
2009-09-24 08:32:27
date last changed
2017-12-10 04:16:41
@article{8ad5c3ed-52ad-41e1-b0ed-eed4e7d419a8,
  abstract     = {The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers.},
  author       = {Korner, Anna and Piculell, Lennart and Iselau, Frida and Wittgren, Bengt and Larsson, Anette},
  issn         = {1420-3049},
  keyword      = {intrinsic viscosity,hydrophilic matrix tablets,release mechanism,PEO,HPMC,dextran},
  language     = {eng},
  number       = {8},
  pages        = {2699--2716},
  publisher    = {Molecular Diversity Preservation International},
  series       = {Molecules},
  title        = {Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets},
  url          = {http://dx.doi.org/10.3390/molecules14082699},
  volume       = {14},
  year         = {2009},
}