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Cell type- and region- dependent coxsackie adenovirus receptor expression in the central nervous system.

Persson, Annette LU ; Fan, Xiaolong LU ; Widegren, Bengt LU and Englund, Elisabet LU orcid (2006) In Journal of Neuro-Oncology 78(1). p.1-6
Abstract
Model systems have shown that adenoviral vector mediated transient gene expression can potentially be applied for the treatment of brain tumours, neurodegenerative diseases and brain injuries. Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. In this report, we have systematically characterized CAR expression in the adult human central nervous system (CNS) by using immunohistochemistry. A total of 85 specimens from various CNS regions were investigated for CAR expression in a cell type-dependent context. The most marked staining positivity was found in the choroid plexus and the pituitary gland. The... (More)
Model systems have shown that adenoviral vector mediated transient gene expression can potentially be applied for the treatment of brain tumours, neurodegenerative diseases and brain injuries. Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. In this report, we have systematically characterized CAR expression in the adult human central nervous system (CNS) by using immunohistochemistry. A total of 85 specimens from various CNS regions were investigated for CAR expression in a cell type-dependent context. The most marked staining positivity was found in the choroid plexus and the pituitary gland. The neocortex had scattered positive neurons, while the white matter was mainly negative. We need to consider the possible adverse effects and the possible damage caused by adenoviral gene therapy if the virus-vector also binds to normal brain cells. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
normal brain, adenoviral gene therapy, coxsackie adenovirus receptor, reactive/inflammatory brain tissue, immunohistochemistry
in
Journal of Neuro-Oncology
volume
78
issue
1
pages
1 - 6
publisher
Springer
external identifiers
  • pmid:16314939
  • wos:000237796100001
  • scopus:33646896230
  • pmid:16314939
ISSN
1573-7373
DOI
10.1007/s11060-005-9055-3
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Genetics (Closed 2011) (011005100), Division of Molecular Medicine and Gene Therapy (013022010), Pathology, (Lund) (013030000)
id
2dd5c708-5a9d-496e-ba2d-9f99bbd0a1df (old id 147701)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16314939&dopt=Abstract
date added to LUP
2016-04-01 17:04:24
date last changed
2021-02-17 02:04:38
@article{2dd5c708-5a9d-496e-ba2d-9f99bbd0a1df,
  abstract     = {Model systems have shown that adenoviral vector mediated transient gene expression can potentially be applied for the treatment of brain tumours, neurodegenerative diseases and brain injuries. Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. In this report, we have systematically characterized CAR expression in the adult human central nervous system (CNS) by using immunohistochemistry. A total of 85 specimens from various CNS regions were investigated for CAR expression in a cell type-dependent context. The most marked staining positivity was found in the choroid plexus and the pituitary gland. The neocortex had scattered positive neurons, while the white matter was mainly negative. We need to consider the possible adverse effects and the possible damage caused by adenoviral gene therapy if the virus-vector also binds to normal brain cells.},
  author       = {Persson, Annette and Fan, Xiaolong and Widegren, Bengt and Englund, Elisabet},
  issn         = {1573-7373},
  language     = {eng},
  number       = {1},
  pages        = {1--6},
  publisher    = {Springer},
  series       = {Journal of Neuro-Oncology},
  title        = {Cell type- and region- dependent coxsackie adenovirus receptor expression in the central nervous system.},
  url          = {https://lup.lub.lu.se/search/ws/files/4866442/625144.pdf},
  doi          = {10.1007/s11060-005-9055-3},
  volume       = {78},
  year         = {2006},
}