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Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

Chang, Yu-mei ; Barrett, Jennifer H. ; Bishop, D. Timothy ; Armstrong, Bruce K. ; Bataille, Veronique ; Bergman, Wilma ; Berwick, Marianne ; Bracci, Paige M. ; Elwood, J. Mark and Ernstoff, Marc S. , et al. (2009) In International Journal of Epidemiology 38(3). p.814-830
Abstract
Background Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude. Methods We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of sun exposure, sunburn and solar keratoses (three studies) with melanoma risk. Pooled odds ratios (pORs) and 95% Bayesian confidence intervals (CIs) were estimated using Bayesian unconditional polytomous logistic random-coefficients models. Results Recreational sun exposure was a risk factor for melanoma on the trunk (pOR 1.7; 95% CI: 1.4-2.2) and limbs (pOR 1.4; 95% CI: 1.1-1.7), but not head and neck (pOR 1.1; 95% CI: 0.8-1.4), across latitudes. Occupational sun exposure was associated with... (More)
Background Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude. Methods We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of sun exposure, sunburn and solar keratoses (three studies) with melanoma risk. Pooled odds ratios (pORs) and 95% Bayesian confidence intervals (CIs) were estimated using Bayesian unconditional polytomous logistic random-coefficients models. Results Recreational sun exposure was a risk factor for melanoma on the trunk (pOR 1.7; 95% CI: 1.4-2.2) and limbs (pOR 1.4; 95% CI: 1.1-1.7), but not head and neck (pOR 1.1; 95% CI: 0.8-1.4), across latitudes. Occupational sun exposure was associated with risk of melanoma on the head and neck at low latitudes (pOR 1.7; 95% CI: 1.0-3.0). Total sun exposure was associated with increased risk of melanoma on the limbs at low latitudes (pOR 1.5; 95% CI: 1.0-2.2), but not at other body sites or other latitudes. The pORs for sunburn in childhood were 1.5 (95% CI: 1.3-1.7), 1.5 (95% CI: 1.3-1.7) and 1.4 (95% CI: 1.1-1.7) for melanoma on the trunk, limbs, and head and neck, respectively, showing little variation across latitudes. The presence of head and neck solar keratoses was associated with increased risk of melanoma on the head and neck (pOR 4.0; 95% CI: 1.7-9.1) and limbs (pOR 4.0; 95% CI: 1.9-8.4). Conclusion Melanoma risk at different body sites is associated with different amounts and patterns of sun exposure. Recreational sun exposure and sunburn are strong predictors of melanoma at all latitudes, whereas measures of occupational and total sun exposure appear to predict melanoma predominately at low latitudes. Keywords Melanoma, recreational sun exposure, occupational sun exposure, total sun exposure, sunburn, solar keratoses (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sun exposure, total, occupational sun exposure, Melanoma, recreational sun exposure, sunburn, solar keratoses
in
International Journal of Epidemiology
volume
38
issue
3
pages
814 - 830
publisher
Oxford University Press
external identifiers
  • wos:000268810100029
  • scopus:66749185326
ISSN
1464-3685
DOI
10.1093/ije/dyp166
language
English
LU publication?
yes
id
b87cbbf5-fae1-4985-a34b-b8418e33fbcd (old id 1478273)
date added to LUP
2016-04-01 11:35:32
date last changed
2021-08-25 01:27:09
@article{b87cbbf5-fae1-4985-a34b-b8418e33fbcd,
  abstract     = {Background Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude. Methods We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of sun exposure, sunburn and solar keratoses (three studies) with melanoma risk. Pooled odds ratios (pORs) and 95% Bayesian confidence intervals (CIs) were estimated using Bayesian unconditional polytomous logistic random-coefficients models. Results Recreational sun exposure was a risk factor for melanoma on the trunk (pOR 1.7; 95% CI: 1.4-2.2) and limbs (pOR 1.4; 95% CI: 1.1-1.7), but not head and neck (pOR 1.1; 95% CI: 0.8-1.4), across latitudes. Occupational sun exposure was associated with risk of melanoma on the head and neck at low latitudes (pOR 1.7; 95% CI: 1.0-3.0). Total sun exposure was associated with increased risk of melanoma on the limbs at low latitudes (pOR 1.5; 95% CI: 1.0-2.2), but not at other body sites or other latitudes. The pORs for sunburn in childhood were 1.5 (95% CI: 1.3-1.7), 1.5 (95% CI: 1.3-1.7) and 1.4 (95% CI: 1.1-1.7) for melanoma on the trunk, limbs, and head and neck, respectively, showing little variation across latitudes. The presence of head and neck solar keratoses was associated with increased risk of melanoma on the head and neck (pOR 4.0; 95% CI: 1.7-9.1) and limbs (pOR 4.0; 95% CI: 1.9-8.4). Conclusion Melanoma risk at different body sites is associated with different amounts and patterns of sun exposure. Recreational sun exposure and sunburn are strong predictors of melanoma at all latitudes, whereas measures of occupational and total sun exposure appear to predict melanoma predominately at low latitudes. Keywords Melanoma, recreational sun exposure, occupational sun exposure, total sun exposure, sunburn, solar keratoses},
  author       = {Chang, Yu-mei and Barrett, Jennifer H. and Bishop, D. Timothy and Armstrong, Bruce K. and Bataille, Veronique and Bergman, Wilma and Berwick, Marianne and Bracci, Paige M. and Elwood, J. Mark and Ernstoff, Marc S. and Gallagher, Richard P. and Green, Adele C. and Gruis, Nelleke A. and Holly, Elizabeth A. and Ingvar, Christian and Kanetsky, Peter A. and Karagas, Margaret R. and Lee, Tim K. and Le Marchand, Loic and Mackie, Rona M. and Olsson, Håkan and Osterlind, Anne and Rebbeck, Timothy R. and Sasieni, Peter and Siskind, Victor and Swerdlow, Anthony J. and Titus-Ernstoff, Linda and Zens, Michael S. and Newton-Bishop, Julia A.},
  issn         = {1464-3685},
  language     = {eng},
  number       = {3},
  pages        = {814--830},
  publisher    = {Oxford University Press},
  series       = {International Journal of Epidemiology},
  title        = {Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls},
  url          = {http://dx.doi.org/10.1093/ije/dyp166},
  doi          = {10.1093/ije/dyp166},
  volume       = {38},
  year         = {2009},
}