Advanced

Hypotermi efter perinatal asfyxi minskar risken för hjärnskada. Men för tidigt att rekommendera rutinmässig behandling

Hellström-Westas, Lena LU (2005) In Läkartidningen 102(42). p.1-3030
Abstract (Swedish)
Måttlig hypotermi efter perinatal asfyxi reducerar

mortaliteten och risken för överlevnad med svårt

handikapp, visar två randomiserade, kontrollerade

studier. Fler studier pågår och förväntas bli publicerade

inom de närmaste åren.

Den publicerade studien visar dock att det endast är

barn med måttlig hjärnskada som har effekt av hypotermi.

Hypotermi efter perinatal asfyxi kan ännu inte rekommenderas

som klinisk rutin. Det behövs mer kunskap

om dosering av hypotermin (duration, optimal temperatur)

i relation till den dominerande skadetypen

(kortikala eller basala ganglier).

Neonatalsektionen anordnade i september 2005 ett

... (More)
Måttlig hypotermi efter perinatal asfyxi reducerar

mortaliteten och risken för överlevnad med svårt

handikapp, visar två randomiserade, kontrollerade

studier. Fler studier pågår och förväntas bli publicerade

inom de närmaste åren.

Den publicerade studien visar dock att det endast är

barn med måttlig hjärnskada som har effekt av hypotermi.

Hypotermi efter perinatal asfyxi kan ännu inte rekommenderas

som klinisk rutin. Det behövs mer kunskap

om dosering av hypotermin (duration, optimal temperatur)

i relation till den dominerande skadetypen

(kortikala eller basala ganglier).

Neonatalsektionen anordnade i september 2005 ett

nationellt expertmöte om återupplivning och hypotermi.

Centra som vill starta hypotermibehandling rekommenderades

att ansluta sig till någon av de pågående

studierna. Möjligheterna att skapa en nordisk

multicenterstudie diskuterades också. (Less)
Abstract
Two randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after birth, for 72 h reduces mortality and survival with severe brain injury. Several issues must, however, be solved before postasphyctic cooling can be recommended as clinical routine. There are no data on optimal duration, degree of cooling, best method, or if methods and degree of cooling should be adapted to type of brain injury. Continued research... (More)
Two randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after birth, for 72 h reduces mortality and survival with severe brain injury. Several issues must, however, be solved before postasphyctic cooling can be recommended as clinical routine. There are no data on optimal duration, degree of cooling, best method, or if methods and degree of cooling should be adapted to type of brain injury. Continued research with randomised controlled trials is recommended. (Less)
Please use this url to cite or link to this publication:
author
organization
alternative title
Hypothermia after perinatal asphyxia reduces the risk of brain damage. But it's too early to recommend the method for routine treatment
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Neonatal asfyxi, Kronisk hjärnskada, Framkallad hypotermi, Hypoxi-ischemi, hjärna
in
Läkartidningen
volume
102
issue
42
pages
1 - 3030
external identifiers
  • pmid:16294526
  • scopus:27644579561
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
e8c4084c-ddd9-45a9-b780-1a9598b18416 (old id 147891)
alternative location
http://ltarkiv.lakartidningen.se/artNo30832
date added to LUP
2007-07-23 13:10:07
date last changed
2017-01-01 06:36:43
@article{e8c4084c-ddd9-45a9-b780-1a9598b18416,
  abstract     = {Two randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after birth, for 72 h reduces mortality and survival with severe brain injury. Several issues must, however, be solved before postasphyctic cooling can be recommended as clinical routine. There are no data on optimal duration, degree of cooling, best method, or if methods and degree of cooling should be adapted to type of brain injury. Continued research with randomised controlled trials is recommended.},
  author       = {Hellström-Westas, Lena},
  issn         = {0023-7205},
  keyword      = {Neonatal asfyxi,Kronisk hjärnskada,Framkallad hypotermi,Hypoxi-ischemi,hjärna},
  language     = {swe},
  number       = {42},
  pages        = {1--3030},
  series       = {Läkartidningen},
  title        = {Hypotermi efter perinatal asfyxi minskar risken för hjärnskada. Men för tidigt att rekommendera rutinmässig behandling},
  volume       = {102},
  year         = {2005},
}