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Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells.

Liu, Fuli LU ; Cheng, Yajun LU ; Wu, Jun LU ; Tauschel, Horst-Dietmar and Duan, Rui-Dong LU (2006) In Cancer Letters 235(1). p.141-146
Abstract
We investigated the effects of UDCA on sphingomyelinase (SMase) in Caco 2 cells cultured in monolayer and polarized conditions. Alkaline SMase activity was high in polarized cells whereas. acid and neutral SMase activities were high in monolayer cells. In polarized cells, UDCA increased alkaline SMase expression and caspase 3 activity but had no effect on acid and neutral SMases. In monolayer cells, UDCA reduced both acid and neutral SMase activities, inhibited cell proliferation, but had little effect on alkaline SMase and caspase 3 activities. In conclusion, UDCA differentially affects SMasc activity, cell proliferation, and apoptosis in colonic cells depending on the cell conditions. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colon cancers, sphingomyelinase, Caco 2 cells, UDCA
in
Cancer Letters
volume
235
issue
1
pages
141 - 146
publisher
Elsevier
external identifiers
  • pmid:16290921
  • wos:000237130400019
  • scopus:33646156070
ISSN
1872-7980
DOI
10.1016/j.canlet.2005.04.016
language
English
LU publication?
yes
id
afae47f5-3383-4aea-b2c8-8916c6ff4b56 (old id 147922)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16290921&dopt=Abstract
date added to LUP
2016-04-01 16:30:40
date last changed
2024-10-11 22:19:43
@article{afae47f5-3383-4aea-b2c8-8916c6ff4b56,
  abstract     = {{We investigated the effects of UDCA on sphingomyelinase (SMase) in Caco 2 cells cultured in monolayer and polarized conditions. Alkaline SMase activity was high in polarized cells whereas. acid and neutral SMase activities were high in monolayer cells. In polarized cells, UDCA increased alkaline SMase expression and caspase 3 activity but had no effect on acid and neutral SMases. In monolayer cells, UDCA reduced both acid and neutral SMase activities, inhibited cell proliferation, but had little effect on alkaline SMase and caspase 3 activities. In conclusion, UDCA differentially affects SMasc activity, cell proliferation, and apoptosis in colonic cells depending on the cell conditions. (c) 2005 Elsevier Ireland Ltd. All rights reserved.}},
  author       = {{Liu, Fuli and Cheng, Yajun and Wu, Jun and Tauschel, Horst-Dietmar and Duan, Rui-Dong}},
  issn         = {{1872-7980}},
  keywords     = {{colon cancers; sphingomyelinase; Caco 2 cells; UDCA}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{141--146}},
  publisher    = {{Elsevier}},
  series       = {{Cancer Letters}},
  title        = {{Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells.}},
  url          = {{https://lup.lub.lu.se/search/files/4694776/625155.pdf}},
  doi          = {{10.1016/j.canlet.2005.04.016}},
  volume       = {{235}},
  year         = {{2006}},
}