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The Epidemiology of Intracerebral Haemorrahge. Risk factors and prognosis

Zia, Elisabet LU (2009) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2009:68.
Abstract
Abstract





The present thesis explored the epidemiology of intracerebral haemorrhage (ICH), i.e., factors associated to incidence and prognosis.



In the population of Malmö (Malmö 1990 cohort), it was shown that immigrants from China/Vietnam and the Former Soviet Union had higher risk of ICH than citizens born in Sweden.



Although hypertension is a well-known risk factor for stroke, the relation between blood pressure (BP) levels and stroke subtypes is less clear. In the Malmö Diet and Cancer cohort

increasing BP was strongly associated with higher incidence of cerebral infarction, as measured by the crude and standardised incidence rates. However, in terms of... (More)
Abstract





The present thesis explored the epidemiology of intracerebral haemorrhage (ICH), i.e., factors associated to incidence and prognosis.



In the population of Malmö (Malmö 1990 cohort), it was shown that immigrants from China/Vietnam and the Former Soviet Union had higher risk of ICH than citizens born in Sweden.



Although hypertension is a well-known risk factor for stroke, the relation between blood pressure (BP) levels and stroke subtypes is less clear. In the Malmö Diet and Cancer cohort

increasing BP was strongly associated with higher incidence of cerebral infarction, as measured by the crude and standardised incidence rates. However, in terms of relative risks (RR), the risk was highest for primary ICH (PICH), especially for nonlobar PICH.



The results of previous studies have indicated differences in pathology and genetics between PICH subtypes by bleeding location. In the Malmö Preventive Project cohort, systolic BP and smoking were found to be associated with increased risk of lobar PICH. Systolic BP, psychiatric morbidity and diabetes were found to be associated with nonlobar PICH..



Of 474 patients with PICH (Malmö Stroke Registry), 26% died within 28 days and 49% within three years. Male sex predicted 28-day and 3-year mortality, largely explained by high 28-day mortality in male patients older than 75 years.



It conclusion, the incidence of ICH varies by country of birth. The impact of high BP, in terms of RR, is highest for nonlobar PICH. Smoking is associated with lobar PICH, and diabetes with nonlobar PICH. Female PICH patients have better survival than men. (Less)
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author
supervisor
opponent
  • Associate Professor Björn, Zethelius, Department of Public Health and Caring Sciences, Uppsala University, Sweden
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Stroke Intracerebral haemorrhage Blood pressure Diabetes Smoking Birth country Ethnicity Risk factors Incidence Prognosis Mortality Recurrence Gender Hjärnblödning Riskfaktorer Prognos
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2009:68
pages
100 pages
publisher
Lund University
defense location
Lecture Hall, Department of Obstetrics and Gynecology, entrance 74, Malmö University Hospital
defense date
2009-10-16 09:30
ISSN
1652-8220
ISBN
978-91-86253-56-1
language
English
LU publication?
yes
id
566a5028-654c-419d-acab-1e78d08710fc (old id 1479422)
date added to LUP
2009-09-24 13:52:17
date last changed
2016-09-19 08:44:48
@phdthesis{566a5028-654c-419d-acab-1e78d08710fc,
  abstract     = {Abstract<br/><br>
<br/><br>
<br/><br>
The present thesis explored the epidemiology of intracerebral haemorrhage (ICH), i.e., factors associated to incidence and prognosis.<br/><br>
<br/><br>
In the population of Malmö (Malmö 1990 cohort), it was shown that immigrants from China/Vietnam and the Former Soviet Union had higher risk of ICH than citizens born in Sweden. <br/><br>
<br/><br>
Although hypertension is a well-known risk factor for stroke, the relation between blood pressure (BP) levels and stroke subtypes is less clear. In the Malmö Diet and Cancer cohort <br/><br>
increasing BP was strongly associated with higher incidence of cerebral infarction, as measured by the crude and standardised incidence rates. However, in terms of relative risks (RR), the risk was highest for primary ICH (PICH), especially for nonlobar PICH.<br/><br>
<br/><br>
The results of previous studies have indicated differences in pathology and genetics between PICH subtypes by bleeding location. In the Malmö Preventive Project cohort, systolic BP and smoking were found to be associated with increased risk of lobar PICH. Systolic BP, psychiatric morbidity and diabetes were found to be associated with nonlobar PICH..<br/><br>
<br/><br>
Of 474 patients with PICH (Malmö Stroke Registry), 26% died within 28 days and 49% within three years. Male sex predicted 28-day and 3-year mortality, largely explained by high 28-day mortality in male patients older than 75 years. <br/><br>
<br/><br>
It conclusion, the incidence of ICH varies by country of birth. The impact of high BP, in terms of RR, is highest for nonlobar PICH. Smoking is associated with lobar PICH, and diabetes with nonlobar PICH. Female PICH patients have better survival than men.},
  author       = {Zia, Elisabet},
  isbn         = {978-91-86253-56-1},
  issn         = {1652-8220},
  keyword      = {Stroke
Intracerebral haemorrhage
Blood pressure
Diabetes
Smoking
Birth country
Ethnicity
Risk factors
Incidence
Prognosis
Mortality
Recurrence
Gender
Hjärnblödning
Riskfaktorer
Prognos},
  language     = {eng},
  pages        = {100},
  publisher    = {Lund University},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {The Epidemiology of Intracerebral Haemorrahge. Risk factors and prognosis},
  volume       = {2009:68},
  year         = {2009},
}