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Risk factors for primary intracerebral hemorrhage : a population-based nested case-control study

Zia, Elisabet LU ; Pessah-Rasmussen, Hélène LU ; Khan, Farhad Ali LU ; Norrving, Bo LU ; Janzon, Lars LU ; Berglund, Göran LU and Engström, Gunnar LU (2006) In Cerebrovascular Diseases 21(1-2). p.18-25
Abstract

PURPOSE: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design.

METHOD: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up period (mean 14 years) were compared with 1,029 stroke-free controls, matched for age, sex and screening-year.

RESULTS: As compared to controls, PICH cases had significantly higher blood pressure (135/91 vs. 127/85 mm Hg), triglycerides (1.7 vs. 1.4 mmol/l), BMI (25.5 vs. 24.8) and shorter stature (1.73 vs. 1.74 m). Diabetes (6.9... (More)

PURPOSE: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design.

METHOD: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up period (mean 14 years) were compared with 1,029 stroke-free controls, matched for age, sex and screening-year.

RESULTS: As compared to controls, PICH cases had significantly higher blood pressure (135/91 vs. 127/85 mm Hg), triglycerides (1.7 vs. 1.4 mmol/l), BMI (25.5 vs. 24.8) and shorter stature (1.73 vs. 1.74 m). Diabetes (6.9 vs. 2.8 %) and history of psychiatric morbidity (19.7 vs. 11.0 %) were more common in PICH cases and more of them were living alone (35.4 vs. 25.5%). After adjustment in a backward logistic regression model, high systolic blood pressure, diabetes, high triglycerides, short stature and psychiatric morbidity remained significantly associated with PICH. As compared to the control group, high systolic blood pressure was significantly associated both with nonlobar and lobar PICH. Diabetes and psychiatric morbidity were associated with nonlobar PICH. Smoking doubled the risk for lobar PICH, but was unrelated to nonlobar PICH.

CONCLUSION: In this prospective population-based study, hypertension, diabetes, height, triglycerides and psychiatric morbidity were risk factors for PICH. Smoking was a risk factor for lobar PICH only.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Body Height, Case-Control Studies, Cerebral Hemorrhage, Cohort Studies, Diabetes Mellitus, Type 2, Female, Humans, Hyperlipidemias, Hypertension, Life Style, Male, Marital Status, Mental Disorders, Middle Aged, Risk Factors, Sweden, Journal Article, Research Support, Non-U.S. Gov't
in
Cerebrovascular Diseases
volume
21
issue
1-2
pages
8 pages
publisher
Karger
external identifiers
  • wos:000234169600003
  • pmid:16286730
  • scopus:30944470203
  • pmid:16286730
ISSN
1421-9786
DOI
10.1159/000089589
language
English
LU publication?
yes
id
5c46c3be-9bbe-4cbc-b570-56d0bdd257dd (old id 147968)
date added to LUP
2016-04-01 12:08:10
date last changed
2022-04-05 18:06:13
@article{5c46c3be-9bbe-4cbc-b570-56d0bdd257dd,
  abstract     = {{<p>PURPOSE: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design.</p><p>METHOD: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up period (mean 14 years) were compared with 1,029 stroke-free controls, matched for age, sex and screening-year.</p><p>RESULTS: As compared to controls, PICH cases had significantly higher blood pressure (135/91 vs. 127/85 mm Hg), triglycerides (1.7 vs. 1.4 mmol/l), BMI (25.5 vs. 24.8) and shorter stature (1.73 vs. 1.74 m). Diabetes (6.9 vs. 2.8 %) and history of psychiatric morbidity (19.7 vs. 11.0 %) were more common in PICH cases and more of them were living alone (35.4 vs. 25.5%). After adjustment in a backward logistic regression model, high systolic blood pressure, diabetes, high triglycerides, short stature and psychiatric morbidity remained significantly associated with PICH. As compared to the control group, high systolic blood pressure was significantly associated both with nonlobar and lobar PICH. Diabetes and psychiatric morbidity were associated with nonlobar PICH. Smoking doubled the risk for lobar PICH, but was unrelated to nonlobar PICH.</p><p>CONCLUSION: In this prospective population-based study, hypertension, diabetes, height, triglycerides and psychiatric morbidity were risk factors for PICH. Smoking was a risk factor for lobar PICH only.</p>}},
  author       = {{Zia, Elisabet and Pessah-Rasmussen, Hélène and Khan, Farhad Ali and Norrving, Bo and Janzon, Lars and Berglund, Göran and Engström, Gunnar}},
  issn         = {{1421-9786}},
  keywords     = {{Adult; Body Height; Case-Control Studies; Cerebral Hemorrhage; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipidemias; Hypertension; Life Style; Male; Marital Status; Mental Disorders; Middle Aged; Risk Factors; Sweden; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{18--25}},
  publisher    = {{Karger}},
  series       = {{Cerebrovascular Diseases}},
  title        = {{Risk factors for primary intracerebral hemorrhage : a population-based nested case-control study}},
  url          = {{http://dx.doi.org/10.1159/000089589}},
  doi          = {{10.1159/000089589}},
  volume       = {{21}},
  year         = {{2006}},
}