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Similar response in male and female B10.RIII mice in a murine model of allergic airway inflammation.

Matheu, Victor LU ; Barrios, Ysamar; Arnau, Maria-Rosa; Navikas, Vaidrius and Issazadeh, Shohreh (2010) In Inflammation Research1995-01-01+01:00 59(4). p.263-269
Abstract
BACKGROUND: Several reports have been published on the gender differences associated with allergies in mice. GOAL: In the present study we investigate the influence of gender on allergy response using a strain of mice, B10.RIII, which is commonly used in the collagen-induced arthritis murine model. METHODS: Both male and female B10.RIII young mice were immunized with OVA and challenged four times with OVA intranasally. Samples were taken 24 h after the last challenge, and eosinophils in bronchoalveolar lavage (BAL) and parenchyma, Th-2 cytokines in BAL, total and antigen-specific IgE in sera, and antigen-specific T-cell proliferation were measured. RESULTS: Immunization in both male and female B10.RIII mice with OVA elicited a classical... (More)
BACKGROUND: Several reports have been published on the gender differences associated with allergies in mice. GOAL: In the present study we investigate the influence of gender on allergy response using a strain of mice, B10.RIII, which is commonly used in the collagen-induced arthritis murine model. METHODS: Both male and female B10.RIII young mice were immunized with OVA and challenged four times with OVA intranasally. Samples were taken 24 h after the last challenge, and eosinophils in bronchoalveolar lavage (BAL) and parenchyma, Th-2 cytokines in BAL, total and antigen-specific IgE in sera, and antigen-specific T-cell proliferation were measured. RESULTS: Immunization in both male and female B10.RIII mice with OVA elicited a classical Th2-type response. Results showed no significant differences among male and female mice. Also a high eosinophilia in BAL fluid and parenchyma was produced in both genders without any significant differences. However, the deviation of both parameters was higher in young males compared to young females. CONCLUSIONS: Gender differences, classically associated with some strains of mice, are not reproducible in B10.RIII mice. Gender differences in murine models of allergic airway inflammation are probably strain-dependent. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Airways, Allergy, Hypersensitivity, Inflammatory models, Asthma
in
Inflammation Research1995-01-01+01:00
volume
59
issue
4
pages
263 - 269
publisher
Birkhaüser
external identifiers
  • wos:000275421400003
  • pmid:19779803
  • scopus:77953075358
ISSN
1420-908X
DOI
10.1007/s00011-009-0094-7
language
English
LU publication?
yes
id
b1e8a6cd-532d-470b-b902-92025a211110 (old id 1483184)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19779803?dopt=Abstract
date added to LUP
2012-01-19 10:41:49
date last changed
2018-05-29 12:12:28
@article{b1e8a6cd-532d-470b-b902-92025a211110,
  abstract     = {BACKGROUND: Several reports have been published on the gender differences associated with allergies in mice. GOAL: In the present study we investigate the influence of gender on allergy response using a strain of mice, B10.RIII, which is commonly used in the collagen-induced arthritis murine model. METHODS: Both male and female B10.RIII young mice were immunized with OVA and challenged four times with OVA intranasally. Samples were taken 24 h after the last challenge, and eosinophils in bronchoalveolar lavage (BAL) and parenchyma, Th-2 cytokines in BAL, total and antigen-specific IgE in sera, and antigen-specific T-cell proliferation were measured. RESULTS: Immunization in both male and female B10.RIII mice with OVA elicited a classical Th2-type response. Results showed no significant differences among male and female mice. Also a high eosinophilia in BAL fluid and parenchyma was produced in both genders without any significant differences. However, the deviation of both parameters was higher in young males compared to young females. CONCLUSIONS: Gender differences, classically associated with some strains of mice, are not reproducible in B10.RIII mice. Gender differences in murine models of allergic airway inflammation are probably strain-dependent.},
  author       = {Matheu, Victor and Barrios, Ysamar and Arnau, Maria-Rosa and Navikas, Vaidrius and Issazadeh, Shohreh},
  issn         = {1420-908X},
  keyword      = {Airways,Allergy,Hypersensitivity,Inflammatory models,Asthma},
  language     = {eng},
  number       = {4},
  pages        = {263--269},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research1995-01-01+01:00},
  title        = {Similar response in male and female B10.RIII mice in a murine model of allergic airway inflammation.},
  url          = {http://dx.doi.org/10.1007/s00011-009-0094-7},
  volume       = {59},
  year         = {2010},
}