Prophylactic therapy in haemophilia.
Ljung, Rolf LU
(2009)
In Blood Reviews
23(6).
p.267-274
- Abstract
- Clinical experience since decades and numerous retro- and, recently, also prospective studies clearly demonstrate that prophylactic treatment, albeit much more expensive, is superior to on-demand treatment regardless if outcome focus on number of joint- or life-threatening bleeds or arthropathy, evaluated by X-ray or MRI, or quality of life measured by general or hemophilia specific instruments. Optimal prophylactic treatment should be started early (primary prophylaxis) but various opinions exist on the dose and dose interval, depending on the objective of treatment in the individual patient which in turn is usually dependent on the resources in the health care system. Secondary prophylaxis, started later in childhood or in adults is... (More)
- Clinical experience since decades and numerous retro- and, recently, also prospective studies clearly demonstrate that prophylactic treatment, albeit much more expensive, is superior to on-demand treatment regardless if outcome focus on number of joint- or life-threatening bleeds or arthropathy, evaluated by X-ray or MRI, or quality of life measured by general or hemophilia specific instruments. Optimal prophylactic treatment should be started early (primary prophylaxis) but various opinions exist on the dose and dose interval, depending on the objective of treatment in the individual patient which in turn is usually dependent on the resources in the health care system. Secondary prophylaxis, started later in childhood or in adults is beneficial but less cost-effective. This review covers proof of concept of primary prophylaxis in children and secondary prophylaxis in adults, comparisons between prophylaxis and on demand treatment as well as outcome measurers, health economics and future trends of prophylactic treatment of hemophilia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483225
- author
- Ljung, Rolf
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood Reviews
- volume
- 23
- issue
- 6
- pages
- 267 - 274
- publisher
- Churchill Livingstone
- external identifiers
-
- wos:000271804200005
- pmid:19775786
- scopus:70349961526
- ISSN
- 1532-1681
- DOI
- 10.1016/j.blre.2009.08.001
- language
- English
- LU publication?
- yes
- id
- f2b19847-e504-4987-98c1-cf2335f2e2fe (old id 1483225)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19775786?dopt=Abstract
- date added to LUP
- 2016-04-01 12:35:59
- date last changed
- 2022-03-29 03:03:08
@article{f2b19847-e504-4987-98c1-cf2335f2e2fe,
abstract = {{Clinical experience since decades and numerous retro- and, recently, also prospective studies clearly demonstrate that prophylactic treatment, albeit much more expensive, is superior to on-demand treatment regardless if outcome focus on number of joint- or life-threatening bleeds or arthropathy, evaluated by X-ray or MRI, or quality of life measured by general or hemophilia specific instruments. Optimal prophylactic treatment should be started early (primary prophylaxis) but various opinions exist on the dose and dose interval, depending on the objective of treatment in the individual patient which in turn is usually dependent on the resources in the health care system. Secondary prophylaxis, started later in childhood or in adults is beneficial but less cost-effective. This review covers proof of concept of primary prophylaxis in children and secondary prophylaxis in adults, comparisons between prophylaxis and on demand treatment as well as outcome measurers, health economics and future trends of prophylactic treatment of hemophilia.}},
author = {{Ljung, Rolf}},
issn = {{1532-1681}},
language = {{eng}},
number = {{6}},
pages = {{267--274}},
publisher = {{Churchill Livingstone}},
series = {{Blood Reviews}},
title = {{Prophylactic therapy in haemophilia.}},
url = {{http://dx.doi.org/10.1016/j.blre.2009.08.001}},
doi = {{10.1016/j.blre.2009.08.001}},
volume = {{23}},
year = {{2009}},
}