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Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.

Cucak, Helena LU ; Yrlid, Ulf; Reizis, Boris; Kalinke, Ulrich and Johansson Lindbom, Bengt LU (2009) In Immunity 31(3). p.491-501
Abstract
T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh... (More)
T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells. (Less)
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Contribution to journal
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published
subject
keywords
Helper-Inducer: metabolism, T-Lymphocytes, Receptor, Interferon alpha-beta: immunology, Receptors, CXCR5: metabolism, Helper-Inducer: cytology, Helper-Inducer: immunology, Interferon alpha-beta: genetics, Interferon alpha-beta: deficiency, Lymph Nodes: metabolism, Lymph Nodes: immunology, Lymph Nodes: cytology, Interleukin-6: biosynthesis, Interferon Type I: immunology, Integrins: metabolism, CD11c: immunology, Antigens, Dendritic Cells: immunology
in
Immunity
volume
31
issue
3
pages
491 - 501
publisher
Cell Press
external identifiers
  • wos:000270525900016
  • pmid:19733096
  • scopus:70249131137
ISSN
1074-7613
DOI
10.1016/j.immuni.2009.07.005
language
English
LU publication?
yes
id
088d5356-6101-4d46-b3b2-399f55bcf0db (old id 1483731)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19733096?dopt=Abstract
date added to LUP
2009-10-07 09:18:21
date last changed
2017-12-10 04:40:54
@article{088d5356-6101-4d46-b3b2-399f55bcf0db,
  abstract     = {T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells.},
  author       = {Cucak, Helena and Yrlid, Ulf and Reizis, Boris and Kalinke, Ulrich and Johansson Lindbom, Bengt},
  issn         = {1074-7613},
  keyword      = {Helper-Inducer: metabolism,T-Lymphocytes,Receptor,Interferon alpha-beta: immunology,Receptors,CXCR5: metabolism,Helper-Inducer: cytology,Helper-Inducer: immunology,Interferon alpha-beta: genetics,Interferon alpha-beta: deficiency,Lymph Nodes: metabolism,Lymph Nodes: immunology,Lymph Nodes: cytology,Interleukin-6: biosynthesis,Interferon Type I: immunology,Integrins: metabolism,CD11c: immunology,Antigens,Dendritic Cells: immunology},
  language     = {eng},
  number       = {3},
  pages        = {491--501},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.},
  url          = {http://dx.doi.org/10.1016/j.immuni.2009.07.005},
  volume       = {31},
  year         = {2009},
}