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Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.

Cucak, Helena LU ; Yrlid, Ulf ; Reizis, Boris ; Kalinke, Ulrich and Johansson Lindbom, Bengt LU (2009) In Immunity 31(3). p.491-501
Abstract
T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh... (More)
T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Helper-Inducer: metabolism, T-Lymphocytes, Receptor, Interferon alpha-beta: immunology, Receptors, CXCR5: metabolism, Helper-Inducer: cytology, Helper-Inducer: immunology, Interferon alpha-beta: genetics, Interferon alpha-beta: deficiency, Lymph Nodes: metabolism, Lymph Nodes: immunology, Lymph Nodes: cytology, Interleukin-6: biosynthesis, Interferon Type I: immunology, Integrins: metabolism, CD11c: immunology, Antigens, Dendritic Cells: immunology
in
Immunity
volume
31
issue
3
pages
491 - 501
publisher
Cell Press
external identifiers
  • wos:000270525900016
  • pmid:19733096
  • scopus:70249131137
  • pmid:19733096
ISSN
1074-7613
DOI
10.1016/j.immuni.2009.07.005
language
English
LU publication?
yes
id
088d5356-6101-4d46-b3b2-399f55bcf0db (old id 1483731)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19733096?dopt=Abstract
date added to LUP
2016-04-04 07:07:14
date last changed
2025-04-04 14:54:33
@article{088d5356-6101-4d46-b3b2-399f55bcf0db,
  abstract     = {{T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells.}},
  author       = {{Cucak, Helena and Yrlid, Ulf and Reizis, Boris and Kalinke, Ulrich and Johansson Lindbom, Bengt}},
  issn         = {{1074-7613}},
  keywords     = {{Helper-Inducer: metabolism; T-Lymphocytes; Receptor; Interferon alpha-beta: immunology; Receptors; CXCR5: metabolism; Helper-Inducer: cytology; Helper-Inducer: immunology; Interferon alpha-beta: genetics; Interferon alpha-beta: deficiency; Lymph Nodes: metabolism; Lymph Nodes: immunology; Lymph Nodes: cytology; Interleukin-6: biosynthesis; Interferon Type I: immunology; Integrins: metabolism; CD11c: immunology; Antigens; Dendritic Cells: immunology}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{491--501}},
  publisher    = {{Cell Press}},
  series       = {{Immunity}},
  title        = {{Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2009.07.005}},
  doi          = {{10.1016/j.immuni.2009.07.005}},
  volume       = {{31}},
  year         = {{2009}},
}