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The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.

Gustafsson, Gunnar LU ; Lira, Claudia Mallea; Johansson, Jon; Wisén, Anita LU ; Wohlfart, Björn LU ; Ekman, Rolf and Westrin, Åsa LU (2009) In Psychiatry Research 169(3). p.244-248
Abstract
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or neuroleptics. Possible associations between plasma plasma-BDNF levels, dexamethasone suppression test cortisol levels and Montgomery-Asberg Depression Rating Scale (MADRS) scores were also tested. No difference in basal BDNF levels between patients and controls was found. BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no... (More)
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or neuroleptics. Possible associations between plasma plasma-BDNF levels, dexamethasone suppression test cortisol levels and Montgomery-Asberg Depression Rating Scale (MADRS) scores were also tested. No difference in basal BDNF levels between patients and controls was found. BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no significant differences between the groups. BDNF levels declined after exercise, but after 60 min of rest BDNF levels showed tendencies to increase again in male patients. No correlation between BDNF and cortisol or MADRS scores was found. We conclude that unmedicated patients with moderate depression and normal activity of the hypothalamic-pituitary-adrenal axis do not have a disturbed peripheral BDNF release during exercise. The BDNF increase 60 min after interruption of exercise in male patients might indicate up-regulated BDNF synthesis, but this needs to be further investigated in future studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychiatry Research
volume
169
issue
3
pages
244 - 248
publisher
Elsevier
external identifiers
  • wos:000271143500010
  • pmid:19729204
  • scopus:70349246314
ISSN
1872-7123
DOI
10.1016/j.psychres.2008.06.030
language
English
LU publication?
yes
id
e3d97b86-a163-43a4-a93a-0aa7a38a693d (old id 1483849)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19729204?dopt=Abstract
date added to LUP
2009-10-06 08:26:04
date last changed
2017-12-10 04:40:53
@article{e3d97b86-a163-43a4-a93a-0aa7a38a693d,
  abstract     = {Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or neuroleptics. Possible associations between plasma plasma-BDNF levels, dexamethasone suppression test cortisol levels and Montgomery-Asberg Depression Rating Scale (MADRS) scores were also tested. No difference in basal BDNF levels between patients and controls was found. BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no significant differences between the groups. BDNF levels declined after exercise, but after 60 min of rest BDNF levels showed tendencies to increase again in male patients. No correlation between BDNF and cortisol or MADRS scores was found. We conclude that unmedicated patients with moderate depression and normal activity of the hypothalamic-pituitary-adrenal axis do not have a disturbed peripheral BDNF release during exercise. The BDNF increase 60 min after interruption of exercise in male patients might indicate up-regulated BDNF synthesis, but this needs to be further investigated in future studies.},
  author       = {Gustafsson, Gunnar and Lira, Claudia Mallea and Johansson, Jon and Wisén, Anita and Wohlfart, Björn and Ekman, Rolf and Westrin, Åsa},
  issn         = {1872-7123},
  language     = {eng},
  number       = {3},
  pages        = {244--248},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.},
  url          = {http://dx.doi.org/10.1016/j.psychres.2008.06.030},
  volume       = {169},
  year         = {2009},
}