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Injury Is a Major Inducer of Epidermal Innate Immune Responses during Wound Healing.

Roupé, Markus LU ; Nybo, Mads; Sjöbring, Ulf LU ; Alberius, Per LU ; Schmidtchen, Artur LU and Sørensen, Ole E LU (2010) In Journal of Investigative Dermatology 130. p.1167-1177
Abstract
We examined the importance of injury for the epidermal innate immune response in human skin wounds. We found that injury, independent of infiltrating inflammatory cells, generated prominent chemotactic activity toward neutrophils in injured skin because of IL-8 production. Furthermore, injury was a major inducer of the expression of antimicrobial (poly)peptides (AMPs) in skin wounds. In human skin, these injury-induced innate immune responses were mediated by activation of the epidermal growth factor receptor (EGFR). Consequently, inhibition of the EGFR blocked both the chemotactic activity generated in injured skin and the expression of the majority of the AMPs. The importance of injury was confirmed in mouse experiments in vivo, in which... (More)
We examined the importance of injury for the epidermal innate immune response in human skin wounds. We found that injury, independent of infiltrating inflammatory cells, generated prominent chemotactic activity toward neutrophils in injured skin because of IL-8 production. Furthermore, injury was a major inducer of the expression of antimicrobial (poly)peptides (AMPs) in skin wounds. In human skin, these injury-induced innate immune responses were mediated by activation of the epidermal growth factor receptor (EGFR). Consequently, inhibition of the EGFR blocked both the chemotactic activity generated in injured skin and the expression of the majority of the AMPs. The importance of injury was confirmed in mouse experiments in vivo, in which injury independent of infection was a potent inducer of AMPs in skin wounds. To our knowledge, these data thereby provide a previously unreported molecular link between injury and neutrophil accumulation and identify the molecular background for the vast expression of IL-8 and AMPs in wounded epidermis. Conceptually, these data show that the growth factor response elicited by injury is important for the recruitment of neutrophils in skin wounds.Journal of Investigative Dermatology advance online publication, 3 September 2009; doi:10.1038/jid.2009.284. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Investigative Dermatology
volume
130
pages
1167 - 1177
publisher
Nature Publishing Group
external identifiers
  • wos:000276251000034
  • pmid:19727116
  • scopus:77949517960
ISSN
1523-1747
DOI
10.1038/jid.2009.284
language
English
LU publication?
yes
id
548df2cc-9105-4fef-a052-808ff9718f97 (old id 1483870)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19727116?dopt=Abstract
date added to LUP
2009-10-06 08:32:37
date last changed
2018-05-29 11:02:37
@article{548df2cc-9105-4fef-a052-808ff9718f97,
  abstract     = {We examined the importance of injury for the epidermal innate immune response in human skin wounds. We found that injury, independent of infiltrating inflammatory cells, generated prominent chemotactic activity toward neutrophils in injured skin because of IL-8 production. Furthermore, injury was a major inducer of the expression of antimicrobial (poly)peptides (AMPs) in skin wounds. In human skin, these injury-induced innate immune responses were mediated by activation of the epidermal growth factor receptor (EGFR). Consequently, inhibition of the EGFR blocked both the chemotactic activity generated in injured skin and the expression of the majority of the AMPs. The importance of injury was confirmed in mouse experiments in vivo, in which injury independent of infection was a potent inducer of AMPs in skin wounds. To our knowledge, these data thereby provide a previously unreported molecular link between injury and neutrophil accumulation and identify the molecular background for the vast expression of IL-8 and AMPs in wounded epidermis. Conceptually, these data show that the growth factor response elicited by injury is important for the recruitment of neutrophils in skin wounds.Journal of Investigative Dermatology advance online publication, 3 September 2009; doi:10.1038/jid.2009.284.},
  author       = {Roupé, Markus and Nybo, Mads and Sjöbring, Ulf and Alberius, Per and Schmidtchen, Artur and Sørensen, Ole E},
  issn         = {1523-1747},
  language     = {eng},
  pages        = {1167--1177},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Investigative Dermatology},
  title        = {Injury Is a Major Inducer of Epidermal Innate Immune Responses during Wound Healing.},
  url          = {http://dx.doi.org/10.1038/jid.2009.284},
  volume       = {130},
  year         = {2010},
}