Advanced

Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities.

Körner, Anna LU ; Larsson, Anette; Andersson, Asa and Piculell, Lennart LU (2010) In Journal of Pharmaceutical Sciences 99. p.1225-1238
Abstract
The aim of the study was to determine and compare the degree of swelling and the swelling kinetics of poly(ethylene oxide) (PEO) hydrophilic matrix tablets without any additives for matrixes with different molecular weight polydispersities. A wide range of "mixed" polydisperse PEO tablets were obtained by mixing two PEO batches with average molecular weights of 10(5) and 2 x 10(6), respectively. These were compared with "single-batch" tablets with narrower mono-modal molecular weight distributions. A texture analyzer (TA) was used to determine, during the entire dissolution process, the thickness of the "gel" layer, the height of the dry tablet core and the total height of the tablet. The release of polymer from the tablet was also... (More)
The aim of the study was to determine and compare the degree of swelling and the swelling kinetics of poly(ethylene oxide) (PEO) hydrophilic matrix tablets without any additives for matrixes with different molecular weight polydispersities. A wide range of "mixed" polydisperse PEO tablets were obtained by mixing two PEO batches with average molecular weights of 10(5) and 2 x 10(6), respectively. These were compared with "single-batch" tablets with narrower mono-modal molecular weight distributions. A texture analyzer (TA) was used to determine, during the entire dissolution process, the thickness of the "gel" layer, the height of the dry tablet core and the total height of the tablet. The release of polymer from the tablet was also measured using a chromatographic method. Both the swelling histories and the polymer release rates varied strongly with molecular weight and agitation rate, whereas the rate of dissolution of the solid core varied much less with molecular weight. For single-batch and mixed tablets, tuned to give the same release rate, the swelling process was found to be very similar, regardless of the molecular polydispersity (between 1.2 and 8.8). These results support a previously proposed dissolution model with the key assumption of a constant critical viscosity, independent of time or polymer molecular weight, at the surface of the gel layer of a dissolving tablet. (c) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pharmaceutical Sciences
volume
99
pages
1225 - 1238
publisher
John Wiley & Sons
external identifiers
  • wos:000275215100011
  • pmid:19718760
  • scopus:76649139439
ISSN
0022-3549
DOI
10.1002/jps.21892
language
English
LU publication?
yes
id
5441a298-c480-4964-a6a4-afcdf0caec74 (old id 1483992)
date added to LUP
2009-10-08 12:08:53
date last changed
2018-05-29 12:27:29
@article{5441a298-c480-4964-a6a4-afcdf0caec74,
  abstract     = {The aim of the study was to determine and compare the degree of swelling and the swelling kinetics of poly(ethylene oxide) (PEO) hydrophilic matrix tablets without any additives for matrixes with different molecular weight polydispersities. A wide range of "mixed" polydisperse PEO tablets were obtained by mixing two PEO batches with average molecular weights of 10(5) and 2 x 10(6), respectively. These were compared with "single-batch" tablets with narrower mono-modal molecular weight distributions. A texture analyzer (TA) was used to determine, during the entire dissolution process, the thickness of the "gel" layer, the height of the dry tablet core and the total height of the tablet. The release of polymer from the tablet was also measured using a chromatographic method. Both the swelling histories and the polymer release rates varied strongly with molecular weight and agitation rate, whereas the rate of dissolution of the solid core varied much less with molecular weight. For single-batch and mixed tablets, tuned to give the same release rate, the swelling process was found to be very similar, regardless of the molecular polydispersity (between 1.2 and 8.8). These results support a previously proposed dissolution model with the key assumption of a constant critical viscosity, independent of time or polymer molecular weight, at the surface of the gel layer of a dissolving tablet. (c) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.},
  author       = {Körner, Anna and Larsson, Anette and Andersson, Asa and Piculell, Lennart},
  issn         = {0022-3549},
  language     = {eng},
  pages        = {1225--1238},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pharmaceutical Sciences},
  title        = {Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities.},
  url          = {http://dx.doi.org/10.1002/jps.21892},
  volume       = {99},
  year         = {2010},
}