Advanced

Dementia with Lewy bodies —an Investigation of Cause and Consequence

Boström, Fredrik LU (2009) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2009:69.
Abstract
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and fronto-temporal dementia.



In summary, this thesis demonstrates important differences between AD and DLB. Paper I and II focus on the ultimate consequences of the disease, including resource consumption and impact on quality of life, and demonstrate much more severe consequences of DLB. Paper III and IV focus on diagnosis and prediction of... (More)
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and fronto-temporal dementia.



In summary, this thesis demonstrates important differences between AD and DLB. Paper I and II focus on the ultimate consequences of the disease, including resource consumption and impact on quality of life, and demonstrate much more severe consequences of DLB. Paper III and IV focus on diagnosis and prediction of disease progression through CSF analysis, and demonstrate a robust increase of CSF Ca and Mg in DLB but not in AD. Furthermore, CSF t-tau, a marker of AD and neurodegeneration, is demonstrated to increase mortality in DLB, but not in AD. These DLB specific CSF findings give us further understanding of the factors that may trigger the disease and determine disease course. Furthermore, CSF Mg and Ca may be a valuable tool in making a DLB diagnosis, especially when the considered differential diagnosis is AD. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Doc Kivipelto, Miia, Aging Research Center, Karolinska Institutet, Stockholm, Sweden
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Lewy body disease, Alzheimers disease, Dementia, Dementia with Lewy bodies
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2009:69
pages
41 pages
publisher
Clinical Memory Research Unit, Lund University
defense location
Clinical research centre, UMAS, Malmö, Sweden
defense date
2009-09-12 09:00
ISSN
1652-8220
ISBN
978-91-86253-57-8
language
English
LU publication?
yes
id
b83b3e8e-c9ee-407a-b633-cf0adc1c5414 (old id 1485546)
date added to LUP
2009-10-20 14:56:14
date last changed
2016-09-19 08:44:46
@phdthesis{b83b3e8e-c9ee-407a-b633-cf0adc1c5414,
  abstract     = {Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and fronto-temporal dementia.<br/><br>
<br/><br>
In summary, this thesis demonstrates important differences between AD and DLB. Paper I and II focus on the ultimate consequences of the disease, including resource consumption and impact on quality of life, and demonstrate much more severe consequences of DLB. Paper III and IV focus on diagnosis and prediction of disease progression through CSF analysis, and demonstrate a robust increase of CSF Ca and Mg in DLB but not in AD. Furthermore, CSF t-tau, a marker of AD and neurodegeneration, is demonstrated to increase mortality in DLB, but not in AD. These DLB specific CSF findings give us further understanding of the factors that may trigger the disease and determine disease course. Furthermore, CSF Mg and Ca may be a valuable tool in making a DLB diagnosis, especially when the considered differential diagnosis is AD.},
  author       = {Boström, Fredrik},
  isbn         = {978-91-86253-57-8},
  issn         = {1652-8220},
  keyword      = {Lewy body disease,Alzheimers disease,Dementia,Dementia with Lewy bodies},
  language     = {eng},
  pages        = {41},
  publisher    = {Clinical Memory Research Unit, Lund University},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Dementia with Lewy bodies —an Investigation of Cause and Consequence},
  volume       = {2009:69},
  year         = {2009},
}