Dementia with Lewy bodies —an Investigation of Cause and Consequence
(2009) In Lund University Faculty of Medicine Doctoral Dissertation Series 2009:69.- Abstract
- Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and fronto-temporal dementia.
In summary, this thesis demonstrates important differences between AD and DLB. Paper I and II focus on the ultimate consequences of the disease, including resource consumption and impact on quality of life, and demonstrate much more severe consequences of DLB. Paper III and IV focus on diagnosis and prediction of... (More) - Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and fronto-temporal dementia.
In summary, this thesis demonstrates important differences between AD and DLB. Paper I and II focus on the ultimate consequences of the disease, including resource consumption and impact on quality of life, and demonstrate much more severe consequences of DLB. Paper III and IV focus on diagnosis and prediction of disease progression through CSF analysis, and demonstrate a robust increase of CSF Ca and Mg in DLB but not in AD. Furthermore, CSF t-tau, a marker of AD and neurodegeneration, is demonstrated to increase mortality in DLB, but not in AD. These DLB specific CSF findings give us further understanding of the factors that may trigger the disease and determine disease course. Furthermore, CSF Mg and Ca may be a valuable tool in making a DLB diagnosis, especially when the considered differential diagnosis is AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1485546
- author
- Boström, Fredrik LU
- supervisor
-
- Elisabet Londos LU
- Oskar Hansson LU
- Lennart Minthon LU
- opponent
-
- Doc Kivipelto, Miia, Aging Research Center, Karolinska Institutet, Stockholm, Sweden
- organization
- publishing date
- 2009
- type
- Thesis
- publication status
- published
- subject
- keywords
- Lewy body disease, Alzheimers disease, Dementia, Dementia with Lewy bodies
- in
- Lund University Faculty of Medicine Doctoral Dissertation Series
- volume
- 2009:69
- pages
- 41 pages
- publisher
- Clinical Memory Research Unit, Lund University
- defense location
- Clinical research centre, UMAS, Malmö, Sweden
- defense date
- 2009-09-12 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-86253-57-8
- language
- English
- LU publication?
- yes
- id
- b83b3e8e-c9ee-407a-b633-cf0adc1c5414 (old id 1485546)
- date added to LUP
- 2016-04-01 13:17:07
- date last changed
- 2019-05-22 02:39:36
@phdthesis{b83b3e8e-c9ee-407a-b633-cf0adc1c5414, abstract = {{Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and fronto-temporal dementia.<br/><br> <br/><br> In summary, this thesis demonstrates important differences between AD and DLB. Paper I and II focus on the ultimate consequences of the disease, including resource consumption and impact on quality of life, and demonstrate much more severe consequences of DLB. Paper III and IV focus on diagnosis and prediction of disease progression through CSF analysis, and demonstrate a robust increase of CSF Ca and Mg in DLB but not in AD. Furthermore, CSF t-tau, a marker of AD and neurodegeneration, is demonstrated to increase mortality in DLB, but not in AD. These DLB specific CSF findings give us further understanding of the factors that may trigger the disease and determine disease course. Furthermore, CSF Mg and Ca may be a valuable tool in making a DLB diagnosis, especially when the considered differential diagnosis is AD.}}, author = {{Boström, Fredrik}}, isbn = {{978-91-86253-57-8}}, issn = {{1652-8220}}, keywords = {{Lewy body disease; Alzheimers disease; Dementia; Dementia with Lewy bodies}}, language = {{eng}}, publisher = {{Clinical Memory Research Unit, Lund University}}, school = {{Lund University}}, series = {{Lund University Faculty of Medicine Doctoral Dissertation Series}}, title = {{Dementia with Lewy bodies —an Investigation of Cause and Consequence}}, url = {{https://lup.lub.lu.se/search/files/3277378/1485549.pdf}}, volume = {{2009:69}}, year = {{2009}}, }