Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

A New Method of Selective, Rapid Cooling of the Brain: An Experimental Study.

Allers, Mats ; Boris-Möller, Fredrik LU ; Lunderquist, Anders LU and Wieloch, Tadeusz LU (2006) In Cardiovascular and Interventional Radiology 29(2). p.260-263
Abstract
Purpose: To determine whether retrograde perfusion of cooled blood into one internal jugular vein (IJV) in the pig can selectively reduce the brain temperature without affecting the core body temperature (CBT). Methods: In 7 domestic pigs, the left IJV was catheterized on one side and a catheter placed with the tip immediately below the rete mirabile. Thermistors were placed in both brain hemispheres and the brain temperature continuously registered. Thermistors placed in the rectum registered the CBT. From a catheter in the right femoral vein blood was aspirated with the aid of a roller pump, passed through a cooling device, and infused into the catheter in the left IJV at an initial rate of 200 ml/min. Results: Immediately after the... (More)
Purpose: To determine whether retrograde perfusion of cooled blood into one internal jugular vein (IJV) in the pig can selectively reduce the brain temperature without affecting the core body temperature (CBT). Methods: In 7 domestic pigs, the left IJV was catheterized on one side and a catheter placed with the tip immediately below the rete mirabile. Thermistors were placed in both brain hemispheres and the brain temperature continuously registered. Thermistors placed in the rectum registered the CBT. From a catheter in the right femoral vein blood was aspirated with the aid of a roller pump, passed through a cooling device, and infused into the catheter in the left IJV at an initial rate of 200 ml/min. Results: Immediately after the start of the infusion of cooled blood (13.8 degrees C) into the IJV, the right brain temperature started to drop from its initial 37.9 degrees C and reached 32 degrees C within 5 min. By increasing the temperature of the perfusate a further drop in the brain temperature was avoided and the brain temperature could be kept around 32 degrees C during the experiment. In 4 of the animals a heating blanket was sufficient to compensate for the slight drop in CBT during the cooling period. Conclusions: We conclude that brain temperature can be reduced in the pig by retrograde perfusion of the internal jugular vein with cooled blood and that the core body temperature can be maintained with the aid of a heating blanket. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain, hypothermia, trauma, stroke, ischemia
in
Cardiovascular and Interventional Radiology
volume
29
issue
2
pages
260 - 263
publisher
Springer
external identifiers
  • wos:000235268300015
  • scopus:32544447030
  • pmid:16362468
ISSN
1432-086X
DOI
10.1007/s00270-004-0271-6
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Anaesthesiology and Intensive Care (013230022), Diagnostic Radiology, (Lund) (013038000), Laboratory for Experimental Brain Research (013041000), Thoracic Surgery (013230027)
id
e69c79b4-b1c8-4103-a19f-92a9519353a9 (old id 148597)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16362468&dopt=Abstract
date added to LUP
2016-04-01 11:37:34
date last changed
2021-02-17 07:00:24
@article{e69c79b4-b1c8-4103-a19f-92a9519353a9,
  abstract     = {Purpose: To determine whether retrograde perfusion of cooled blood into one internal jugular vein (IJV) in the pig can selectively reduce the brain temperature without affecting the core body temperature (CBT). Methods: In 7 domestic pigs, the left IJV was catheterized on one side and a catheter placed with the tip immediately below the rete mirabile. Thermistors were placed in both brain hemispheres and the brain temperature continuously registered. Thermistors placed in the rectum registered the CBT. From a catheter in the right femoral vein blood was aspirated with the aid of a roller pump, passed through a cooling device, and infused into the catheter in the left IJV at an initial rate of 200 ml/min. Results: Immediately after the start of the infusion of cooled blood (13.8 degrees C) into the IJV, the right brain temperature started to drop from its initial 37.9 degrees C and reached 32 degrees C within 5 min. By increasing the temperature of the perfusate a further drop in the brain temperature was avoided and the brain temperature could be kept around 32 degrees C during the experiment. In 4 of the animals a heating blanket was sufficient to compensate for the slight drop in CBT during the cooling period. Conclusions: We conclude that brain temperature can be reduced in the pig by retrograde perfusion of the internal jugular vein with cooled blood and that the core body temperature can be maintained with the aid of a heating blanket.},
  author       = {Allers, Mats and Boris-Möller, Fredrik and Lunderquist, Anders and Wieloch, Tadeusz},
  issn         = {1432-086X},
  language     = {eng},
  number       = {2},
  pages        = {260--263},
  publisher    = {Springer},
  series       = {Cardiovascular and Interventional Radiology},
  title        = {A New Method of Selective, Rapid Cooling of the Brain: An Experimental Study.},
  url          = {http://dx.doi.org/10.1007/s00270-004-0271-6},
  doi          = {10.1007/s00270-004-0271-6},
  volume       = {29},
  year         = {2006},
}