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Occupation, Marital Status, and Low-Grade Inflammation. Mutual Confounding or Independent Cardiovascular Risk Factors?

Engström, Gunnar LU ; Hedblad, Bo LU ; Rosvall, Maria LU ; Janzon, Lars LU and Lindgärde, Folke LU (2006) In Arteriosclerosis, Thrombosis and Vascular Biology 26(Dec 15). p.643-648
Abstract
Objective - We explored the relationships between inflammatory proteins, occupation, and marital status, and their independent associations with incidence of cardiovascular disease ( CVD). Methods and Results - Five inflammation-sensitive proteins ( ISPs) ( fibrinogen, ceruloplasmin, haptoglobin, alpha 1-antitrypsin, orosomucoid) were measured in 6075 apparently healthy men. Incidence of coronary events and stroke was followed over 18 years in relation to occupation and marital status. All ISPs showed higher concentrations in divorced men and in manual workers. Except for fibrinogen, this remained significant after adjustments for confounding factors. Adjusted for traditional cardiovascular risk factors, incidence of coronary events was... (More)
Objective - We explored the relationships between inflammatory proteins, occupation, and marital status, and their independent associations with incidence of cardiovascular disease ( CVD). Methods and Results - Five inflammation-sensitive proteins ( ISPs) ( fibrinogen, ceruloplasmin, haptoglobin, alpha 1-antitrypsin, orosomucoid) were measured in 6075 apparently healthy men. Incidence of coronary events and stroke was followed over 18 years in relation to occupation and marital status. All ISPs showed higher concentrations in divorced men and in manual workers. Except for fibrinogen, this remained significant after adjustments for confounding factors. Adjusted for traditional cardiovascular risk factors, incidence of coronary events was significantly increased in unskilled manual workers and in divorced men. The relative risks were slightly reduced after further adjustments for ISPs ( from 1.79 to 1.70 in unskilled manual workers; from 1.58 to 1.51 in divorced men). All ISPs were significantly associated with incidence of coronary events, after adjustments for traditional risk factors. This relationship was essentially unchanged after further adjustments for occupation and marital status. Conclusion - Inflammation could contribute to, but not fully explain, the increased cardiovascular risk in manual workers and divorced men. Although the ISPs vary greatly by occupational and marital status, this does not confound the relationship between ISPs and incidence of CVD. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inflammation, acute coronary syndromes, epidemiology, stroke, socioeconomic
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
26
issue
Dec 15
pages
643 - 648
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:16357315
  • wos:000235372600032
  • scopus:33646572267
  • pmid:16357315
ISSN
1524-4636
DOI
10.1161/01.ATV.0000200100.14612.bb
language
English
LU publication?
yes
id
b186b8d9-44d8-45c4-9394-393f398e9792 (old id 148668)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16357315&dopt=Abstract
date added to LUP
2016-04-01 11:35:16
date last changed
2021-10-06 05:27:37
@article{b186b8d9-44d8-45c4-9394-393f398e9792,
  abstract     = {Objective - We explored the relationships between inflammatory proteins, occupation, and marital status, and their independent associations with incidence of cardiovascular disease ( CVD). Methods and Results - Five inflammation-sensitive proteins ( ISPs) ( fibrinogen, ceruloplasmin, haptoglobin, alpha 1-antitrypsin, orosomucoid) were measured in 6075 apparently healthy men. Incidence of coronary events and stroke was followed over 18 years in relation to occupation and marital status. All ISPs showed higher concentrations in divorced men and in manual workers. Except for fibrinogen, this remained significant after adjustments for confounding factors. Adjusted for traditional cardiovascular risk factors, incidence of coronary events was significantly increased in unskilled manual workers and in divorced men. The relative risks were slightly reduced after further adjustments for ISPs ( from 1.79 to 1.70 in unskilled manual workers; from 1.58 to 1.51 in divorced men). All ISPs were significantly associated with incidence of coronary events, after adjustments for traditional risk factors. This relationship was essentially unchanged after further adjustments for occupation and marital status. Conclusion - Inflammation could contribute to, but not fully explain, the increased cardiovascular risk in manual workers and divorced men. Although the ISPs vary greatly by occupational and marital status, this does not confound the relationship between ISPs and incidence of CVD.},
  author       = {Engström, Gunnar and Hedblad, Bo and Rosvall, Maria and Janzon, Lars and Lindgärde, Folke},
  issn         = {1524-4636},
  language     = {eng},
  number       = {Dec 15},
  pages        = {643--648},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Occupation, Marital Status, and Low-Grade Inflammation. Mutual Confounding or Independent Cardiovascular Risk Factors?},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000200100.14612.bb},
  doi          = {10.1161/01.ATV.0000200100.14612.bb},
  volume       = {26},
  year         = {2006},
}