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Epicardial and endocardial dispersion of ventricular repolarization. A study of monophasic action potential mapping in healthy pigs.

Kongstad Rasmussen, Ole LU ; Xia, Yunlong LU ; Liang, Yanchun; Hertervig, Eva LU ; Ljungstrom, Erik; Olsson, Bertil LU and Yuan, Shiwen LU (2005) In Scandinavian Cardiovascular Journal 39(6). p.342-347
Abstract
Objectives. To investigate the total dispersion of ventricular repolarization of the epi- and endocardium. Design. Monophasic action potentials (MAP) were recorded from 211 +/- 54 (151-353) left and right ventricular epi- and endocardial sites during atrial pacing in 10 pigs using the CARTO system. The activation time (AT), MAP duration (MAPd) and end of repolarization time (EOR) were measured. Results. The total dispersion of AT, EOR and MAPd, defined as the maximal differences of these parameters over both the epi- and endocardium, were 57 +/- 10, 84 +/- 20, and 75 +/- 21 ms respectively and were significantly larger than the respective epi- and endocardial dispersions (p < 0.05). The epicardial dispersion of AT, EOR and MAPd of both... (More)
Objectives. To investigate the total dispersion of ventricular repolarization of the epi- and endocardium. Design. Monophasic action potentials (MAP) were recorded from 211 +/- 54 (151-353) left and right ventricular epi- and endocardial sites during atrial pacing in 10 pigs using the CARTO system. The activation time (AT), MAP duration (MAPd) and end of repolarization time (EOR) were measured. Results. The total dispersion of AT, EOR and MAPd, defined as the maximal differences of these parameters over both the epi- and endocardium, were 57 +/- 10, 84 +/- 20, and 75 +/- 21 ms respectively and were significantly larger than the respective epi- and endocardial dispersions (p < 0.05). The epicardial dispersion of AT, EOR and MAPd of both the right and left ventricles were significantly larger than that of each ventricle alone (p < 0.02). Sternotomy did not affect these dispersion parameters. Conclusion. Detailed mapping of epicardial repolarization in vivo using the MAP mapping technique is feasible. Both the epi- and endocardium of the two ventricles contribute significantly to the total dispersion of repolarization. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Repolarization, endocardium, epicardium, dispersion, MAP mapping
in
Scandinavian Cardiovascular Journal
volume
39
issue
6
pages
342 - 347
publisher
Taylor & Francis
external identifiers
  • pmid:16352486
  • wos:000234092300004
  • scopus:31344472214
ISSN
1651-2006
DOI
10.1080/14017430500188744
language
English
LU publication?
yes
id
bfc6fd09-9f2d-4c2b-b31e-4748268f4927 (old id 148713)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16352486&dopt=Abstract
date added to LUP
2007-07-11 11:49:02
date last changed
2017-01-01 07:08:48
@article{bfc6fd09-9f2d-4c2b-b31e-4748268f4927,
  abstract     = {Objectives. To investigate the total dispersion of ventricular repolarization of the epi- and endocardium. Design. Monophasic action potentials (MAP) were recorded from 211 +/- 54 (151-353) left and right ventricular epi- and endocardial sites during atrial pacing in 10 pigs using the CARTO system. The activation time (AT), MAP duration (MAPd) and end of repolarization time (EOR) were measured. Results. The total dispersion of AT, EOR and MAPd, defined as the maximal differences of these parameters over both the epi- and endocardium, were 57 +/- 10, 84 +/- 20, and 75 +/- 21 ms respectively and were significantly larger than the respective epi- and endocardial dispersions (p &lt; 0.05). The epicardial dispersion of AT, EOR and MAPd of both the right and left ventricles were significantly larger than that of each ventricle alone (p &lt; 0.02). Sternotomy did not affect these dispersion parameters. Conclusion. Detailed mapping of epicardial repolarization in vivo using the MAP mapping technique is feasible. Both the epi- and endocardium of the two ventricles contribute significantly to the total dispersion of repolarization.},
  author       = {Kongstad Rasmussen, Ole and Xia, Yunlong and Liang, Yanchun and Hertervig, Eva and Ljungstrom, Erik and Olsson, Bertil and Yuan, Shiwen},
  issn         = {1651-2006},
  keyword      = {Repolarization,endocardium,epicardium,dispersion,MAP mapping},
  language     = {eng},
  number       = {6},
  pages        = {342--347},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Epicardial and endocardial dispersion of ventricular repolarization. A study of monophasic action potential mapping in healthy pigs.},
  url          = {http://dx.doi.org/10.1080/14017430500188744},
  volume       = {39},
  year         = {2005},
}