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High concentration of kynurenic acid in bile and pancreatic juice

Paluszkiewicz, Piotr; Zgrajka, Wojciech; Saran, Tomasz; Schabowski, Janusz; Piedra, Jose L. Valverde; Fedkiv, Olexandr LU ; Rengman, Sofia LU ; Pierzynowski, Stefan LU and Turski, Waldemar A. (2009) In Amino Acids 37(4). p.637-641
Abstract
Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography. The mean concentrations of KYNA in human gastric juice is 9.91 +/- A 0.71 nM in contrast to human bile (832.5 +/- A 204.1 and 306.8 +/- A 35.2 nM) obtained from patients with cholecystolithiasis and obstructive jaundice, respectively. In pigs, the KYNA levels in bile and pancreatic juice are 1,113.3 +/- A 63.34 and 757.0 +/- A 394.4 nM, respectively. The KYNA concentration increases along the digestive... (More)
Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography. The mean concentrations of KYNA in human gastric juice is 9.91 +/- A 0.71 nM in contrast to human bile (832.5 +/- A 204.1 and 306.8 +/- A 35.2 nM) obtained from patients with cholecystolithiasis and obstructive jaundice, respectively. In pigs, the KYNA levels in bile and pancreatic juice are 1,113.3 +/- A 63.34 and 757.0 +/- A 394.4 nM, respectively. The KYNA concentration increases along the digestive system, reaching 1,638 nM in the colon content. We suggest that the liver and pancreas affect the content of kynurenic acid in the lumen of the digestive tract. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gastric juice, Kynurenic acid, Bile, Pancreatic juice
in
Amino Acids
volume
37
issue
4
pages
637 - 641
publisher
Springer
external identifiers
  • wos:000270280400011
  • scopus:70349602540
ISSN
0939-4451
DOI
10.1007/s00726-008-0183-x
language
English
LU publication?
yes
id
a91f8a52-3849-48b9-95c2-04ae8b5c47cd (old id 1489843)
date added to LUP
2009-10-21 11:16:40
date last changed
2017-05-28 03:39:52
@article{a91f8a52-3849-48b9-95c2-04ae8b5c47cd,
  abstract     = {Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography. The mean concentrations of KYNA in human gastric juice is 9.91 +/- A 0.71 nM in contrast to human bile (832.5 +/- A 204.1 and 306.8 +/- A 35.2 nM) obtained from patients with cholecystolithiasis and obstructive jaundice, respectively. In pigs, the KYNA levels in bile and pancreatic juice are 1,113.3 +/- A 63.34 and 757.0 +/- A 394.4 nM, respectively. The KYNA concentration increases along the digestive system, reaching 1,638 nM in the colon content. We suggest that the liver and pancreas affect the content of kynurenic acid in the lumen of the digestive tract.},
  author       = {Paluszkiewicz, Piotr and Zgrajka, Wojciech and Saran, Tomasz and Schabowski, Janusz and Piedra, Jose L. Valverde and Fedkiv, Olexandr and Rengman, Sofia and Pierzynowski, Stefan and Turski, Waldemar A.},
  issn         = {0939-4451},
  keyword      = {Gastric juice,Kynurenic acid,Bile,Pancreatic juice},
  language     = {eng},
  number       = {4},
  pages        = {637--641},
  publisher    = {Springer},
  series       = {Amino Acids},
  title        = {High concentration of kynurenic acid in bile and pancreatic juice},
  url          = {http://dx.doi.org/10.1007/s00726-008-0183-x},
  volume       = {37},
  year         = {2009},
}