Colorectal cancer risk in association with colorectal cancer as a second malignancy in relatives : a nationwide cohort study
Zheng, Guoqiao LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU
(2022)
In BMC Cancer
22.
p.1-8
- Abstract
BACKGROUND: Increasing number of individuals will have first-degree relatives (FDRs) diagnosed with colorectal cancer (CRC), as a second primary malignancy (CRCa-2) after a non-CRC cancer. We aimed to estimate whether and to what extent a family history of CRCa-2 is associated with an increased CRC risk.
METHODS: In this Swedish nationwide cohort study, rate ratio (RR) and cumulative incidence of CRC were estimated among 172,531 individuals with a family history of CRC as a first primary malignancy (CRCa-1) and 17,830 with a family history of CRCa-2, respectively, using individuals without cancer family history as the reference group.
RESULTS: A cumulative incidence of CRC by age 80 was 6.3 and 5.6% for individuals with a... (More)
BACKGROUND: Increasing number of individuals will have first-degree relatives (FDRs) diagnosed with colorectal cancer (CRC), as a second primary malignancy (CRCa-2) after a non-CRC cancer. We aimed to estimate whether and to what extent a family history of CRCa-2 is associated with an increased CRC risk.
METHODS: In this Swedish nationwide cohort study, rate ratio (RR) and cumulative incidence of CRC were estimated among 172,531 individuals with a family history of CRC as a first primary malignancy (CRCa-1) and 17,830 with a family history of CRCa-2, respectively, using individuals without cancer family history as the reference group.
RESULTS: A cumulative incidence of CRC by age 80 was 6.3 and 5.6% for individuals with a parental and a sibling family history of CRCa-2, respectively. RRs of CRC for one FDR diagnosed with CRCa-1 and CRCa-2 were respectively 1.72 (95% CI, 1.65-1.79) and 1.50 (1.32-1.70); the latter RR was lower than the former (P = 0.0356), but no difference was observed after adjusting age of diagnosis of CRC in FDR and family relationship (P = 0.6898). Increased RRs were found to be associated with a CRCa-2 diagnosis in FDR that occured after cancers in upper aerodigestive tract, breast, prostate, kidney and nervous system.
CONCLUSIONS: Individuals who have relatives with CRCa-2 have an increased risk of CRC, but the magnitude is lower than those having relatives with CRCa-1, which is related to different ages of diagnosis of CRC in FDR and family relationships.
(Less)
- author
- Zheng, Guoqiao
LU
; Sundquist, Jan
LU
; Sundquist, Kristina
LU
and Ji, Jianguang
LU
- organization
- publishing date
- 2022-08-18
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, 80 and over, Cohort Studies, Colorectal Neoplasms/pathology, Genetic Predisposition to Disease, Humans, Incidence, Male, Neoplasms, Second Primary/epidemiology, Risk, Risk Factors
- in
- BMC Cancer
- volume
- 22
- article number
- 902
- pages
- 1 - 8
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:35982395
- scopus:85136110011
- ISSN
- 1471-2407
- DOI
- 10.1186/s12885-022-10000-z
- language
- English
- LU publication?
- yes
- additional info
- © 2022. The Author(s).
- id
- 148fa002-1fd8-45d0-a658-3f3c3e8474df
- date added to LUP
- 2022-08-26 10:36:54
- date last changed
- 2025-01-24 17:56:32
@article{148fa002-1fd8-45d0-a658-3f3c3e8474df,
abstract = {{<p>BACKGROUND: Increasing number of individuals will have first-degree relatives (FDRs) diagnosed with colorectal cancer (CRC), as a second primary malignancy (CRCa-2) after a non-CRC cancer. We aimed to estimate whether and to what extent a family history of CRCa-2 is associated with an increased CRC risk.</p><p>METHODS: In this Swedish nationwide cohort study, rate ratio (RR) and cumulative incidence of CRC were estimated among 172,531 individuals with a family history of CRC as a first primary malignancy (CRCa-1) and 17,830 with a family history of CRCa-2, respectively, using individuals without cancer family history as the reference group.</p><p>RESULTS: A cumulative incidence of CRC by age 80 was 6.3 and 5.6% for individuals with a parental and a sibling family history of CRCa-2, respectively. RRs of CRC for one FDR diagnosed with CRCa-1 and CRCa-2 were respectively 1.72 (95% CI, 1.65-1.79) and 1.50 (1.32-1.70); the latter RR was lower than the former (P = 0.0356), but no difference was observed after adjusting age of diagnosis of CRC in FDR and family relationship (P = 0.6898). Increased RRs were found to be associated with a CRCa-2 diagnosis in FDR that occured after cancers in upper aerodigestive tract, breast, prostate, kidney and nervous system.</p><p>CONCLUSIONS: Individuals who have relatives with CRCa-2 have an increased risk of CRC, but the magnitude is lower than those having relatives with CRCa-1, which is related to different ages of diagnosis of CRC in FDR and family relationships.</p>}},
author = {{Zheng, Guoqiao and Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang}},
issn = {{1471-2407}},
keywords = {{Aged, 80 and over; Cohort Studies; Colorectal Neoplasms/pathology; Genetic Predisposition to Disease; Humans; Incidence; Male; Neoplasms, Second Primary/epidemiology; Risk; Risk Factors}},
language = {{eng}},
month = {{08}},
pages = {{1--8}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cancer}},
title = {{Colorectal cancer risk in association with colorectal cancer as a second malignancy in relatives : a nationwide cohort study}},
url = {{http://dx.doi.org/10.1186/s12885-022-10000-z}},
doi = {{10.1186/s12885-022-10000-z}},
volume = {{22}},
year = {{2022}},
}