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Physicochemical Characterization of Simulated Intestinal Fed-State Fluids Containing Lyso-Phosphatidylcholine and Cholesterol

Fatouros, D. G.; Walrand, I.; Bergenståhl, Björn LU and Mullertz, A. (2009) In Dissolution Technologies 16(3). p.47-50
Abstract
An array of simulated intestinal fed-state fluids, where phosphatidylcholine (PC) was replaced by lysophosphatidylcholine (LPC) and cholesterol (Chol) was added, were visualized with Cryogenic Transmission Electron Microscopy (Cryo-TEM). Micelles were the dominating structural features, emphasizing the micellar-forming characteristics of LPC. Upon increase of the monoglyceride (MG) level, unilamellar vesicles and multivesicular structures were formed. These findings suggest the solubilization of poorly soluble drugs might be affected by the intermediate colloidal phases produced in the gastrointestinal tract.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dissolution Technologies
volume
16
issue
3
pages
47 - 50
publisher
Dissolution Technologies, Inc
external identifiers
  • wos:000270073400006
  • scopus:70349479709
ISSN
1521-298X
language
English
LU publication?
yes
id
70ef7cf5-5a48-4503-9ebb-f482503d12fd (old id 1490113)
date added to LUP
2009-10-19 15:32:51
date last changed
2017-01-01 06:33:56
@article{70ef7cf5-5a48-4503-9ebb-f482503d12fd,
  abstract     = {An array of simulated intestinal fed-state fluids, where phosphatidylcholine (PC) was replaced by lysophosphatidylcholine (LPC) and cholesterol (Chol) was added, were visualized with Cryogenic Transmission Electron Microscopy (Cryo-TEM). Micelles were the dominating structural features, emphasizing the micellar-forming characteristics of LPC. Upon increase of the monoglyceride (MG) level, unilamellar vesicles and multivesicular structures were formed. These findings suggest the solubilization of poorly soluble drugs might be affected by the intermediate colloidal phases produced in the gastrointestinal tract.},
  author       = {Fatouros, D. G. and Walrand, I. and Bergenståhl, Björn and Mullertz, A.},
  issn         = {1521-298X},
  language     = {eng},
  number       = {3},
  pages        = {47--50},
  publisher    = {Dissolution Technologies, Inc},
  series       = {Dissolution Technologies},
  title        = {Physicochemical Characterization of Simulated Intestinal Fed-State Fluids Containing Lyso-Phosphatidylcholine and Cholesterol},
  volume       = {16},
  year         = {2009},
}