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White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study

van de Pol, L. A. ; Verhey, F. ; Frisoni, G. B. ; Tsolaki, M. ; Papapostolou, P. ; Nobili, F. ; Wahlund, L-O ; Minthon, Lennart LU ; Froelich, L. and Hampel, H. , et al. (2009) In Journal of Neurology, Neurosurgery and Psychiatry 80(10). p.1069-1074
Abstract
Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0-4) and white matter hyperintensities (WMH) (0-30) were assessed. Results: Severity of MTA differed between MCI subtypes (p < 0.001), increasing from a mean of 0.8 (SD 0.7) in subjective complaints (n = 77) to 1.3 (0.8) in non-amnestic MCI (n = 93), and from 1.4 (0.9) in single domain amnestic MCI (n = 70) to 1.7... (More)
Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0-4) and white matter hyperintensities (WMH) (0-30) were assessed. Results: Severity of MTA differed between MCI subtypes (p < 0.001), increasing from a mean of 0.8 (SD 0.7) in subjective complaints (n = 77) to 1.3 (0.8) in non-amnestic MCI (n = 93), and from 1.4 (0.9) in single domain amnestic MCI (n = 70) to 1.7 (0.9) in multiple domain amnestic MCI (n = 89). The association between MCI subtype and MTA was modified by age and mainly present in subjects >70 years of age. Severity of WMH did not differ between MCI subtypes (p = 0.21). However, the combination of MTA and WMH differed between MCI subtypes (p = 0.02) Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neurology, Neurosurgery and Psychiatry
volume
80
issue
10
pages
1069 - 1074
publisher
BMJ Publishing Group
external identifiers
  • wos:000269942600005
  • scopus:70349653652
  • pmid:19541689
ISSN
1468-330X
DOI
10.1136/jnnp.2008.158881
language
English
LU publication?
yes
id
553ff427-5ce5-43ac-8e04-c8a7f8285139 (old id 1490655)
date added to LUP
2016-04-01 14:46:14
date last changed
2022-01-28 02:25:50
@article{553ff427-5ce5-43ac-8e04-c8a7f8285139,
  abstract     = {{Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0-4) and white matter hyperintensities (WMH) (0-30) were assessed. Results: Severity of MTA differed between MCI subtypes (p &lt; 0.001), increasing from a mean of 0.8 (SD 0.7) in subjective complaints (n = 77) to 1.3 (0.8) in non-amnestic MCI (n = 93), and from 1.4 (0.9) in single domain amnestic MCI (n = 70) to 1.7 (0.9) in multiple domain amnestic MCI (n = 89). The association between MCI subtype and MTA was modified by age and mainly present in subjects &gt;70 years of age. Severity of WMH did not differ between MCI subtypes (p = 0.21). However, the combination of MTA and WMH differed between MCI subtypes (p = 0.02) Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.}},
  author       = {{van de Pol, L. A. and Verhey, F. and Frisoni, G. B. and Tsolaki, M. and Papapostolou, P. and Nobili, F. and Wahlund, L-O and Minthon, Lennart and Froelich, L. and Hampel, H. and Soininen, H. and Knol, D. L. and Barkhof, F. and Scheltens, P. and Visser, P. J.}},
  issn         = {{1468-330X}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1069--1074}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Journal of Neurology, Neurosurgery and Psychiatry}},
  title        = {{White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study}},
  url          = {{http://dx.doi.org/10.1136/jnnp.2008.158881}},
  doi          = {{10.1136/jnnp.2008.158881}},
  volume       = {{80}},
  year         = {{2009}},
}