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An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow

Bonneaud, C; Richard, M; Faivre, B; Westerdahl, Helena LU and Sorci, G (2005) In Immunogenetics 57(10). p.782-789
Abstract
The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to... (More)
The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to their Mhc class I genotypes. The total number of Mhc alleles had no influence on either primary or secondary response to the two antigens. One particular Mhc allele, however, was associated with an increased response to both antigens. Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunogenetics
volume
57
issue
10
pages
782 - 789
publisher
Springer
external identifiers
  • pmid:16189664
  • wos:000233239500008
  • scopus:27744514294
ISSN
1432-1211
DOI
10.1007/s00251-005-0046-5
language
English
LU publication?
yes
id
b46b055c-33ac-430d-843a-0b1b012d4142 (old id 149181)
date added to LUP
2007-06-25 14:14:04
date last changed
2017-09-10 03:39:11
@article{b46b055c-33ac-430d-843a-0b1b012d4142,
  abstract     = {The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to their Mhc class I genotypes. The total number of Mhc alleles had no influence on either primary or secondary response to the two antigens. One particular Mhc allele, however, was associated with an increased response to both antigens. Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species.},
  author       = {Bonneaud, C and Richard, M and Faivre, B and Westerdahl, Helena and Sorci, G},
  issn         = {1432-1211},
  language     = {eng},
  number       = {10},
  pages        = {782--789},
  publisher    = {Springer},
  series       = {Immunogenetics},
  title        = {An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow},
  url          = {http://dx.doi.org/10.1007/s00251-005-0046-5},
  volume       = {57},
  year         = {2005},
}