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Mechanisms underlying the end-to-side nerve regeneration

Bontioti, Eleana LU and Dahlin, Lars LU (2009) In International Review of Neurobiology 87. p.251-268
Abstract
End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and terminal regenerating sprouting from the donor nerve. A variety of experimental models, most commonly in the lower and upper extremity of rats, and techniques have been used to shed light on the mechanisms. Retrograde labeling techniques have revealed that collateral sprouting do occur, but is probably, at least as observed in long-term experiments,... (More)
End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and terminal regenerating sprouting from the donor nerve. A variety of experimental models, most commonly in the lower and upper extremity of rats, and techniques have been used to shed light on the mechanisms. Retrograde labeling techniques have revealed that collateral sprouting do occur, but is probably, at least as observed in long-term experiments, less important over time. Pruning of branching nerve fibers, induced by the collateral sprouting, is an additional mechanism in this context. Experiments have also focused on the stimuli, including the question of epineurial or perineurial windows, that trigger the sprouting of axons form the donor nerve, which can detected by the use of markers of cellular injury. In die present article, we review studies contributing to clarifications of mechanisms of end-to-side nerve repair, including used experimental techniques. We also stress the importance of the plastic brain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Review of Neurobiology
volume
87
pages
251 - 268
publisher
Elsevier
external identifiers
  • wos:000269657600012
  • scopus:70349784421
ISSN
0074-7742
DOI
10.1016/S0074-7742(09)87012-8
language
English
LU publication?
yes
id
55796f7a-a290-4e96-b845-e0fe1283836b (old id 1492377)
date added to LUP
2009-10-16 15:44:55
date last changed
2017-05-28 04:04:48
@article{55796f7a-a290-4e96-b845-e0fe1283836b,
  abstract     = {End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and terminal regenerating sprouting from the donor nerve. A variety of experimental models, most commonly in the lower and upper extremity of rats, and techniques have been used to shed light on the mechanisms. Retrograde labeling techniques have revealed that collateral sprouting do occur, but is probably, at least as observed in long-term experiments, less important over time. Pruning of branching nerve fibers, induced by the collateral sprouting, is an additional mechanism in this context. Experiments have also focused on the stimuli, including the question of epineurial or perineurial windows, that trigger the sprouting of axons form the donor nerve, which can detected by the use of markers of cellular injury. In die present article, we review studies contributing to clarifications of mechanisms of end-to-side nerve repair, including used experimental techniques. We also stress the importance of the plastic brain.},
  author       = {Bontioti, Eleana and Dahlin, Lars},
  issn         = {0074-7742},
  language     = {eng},
  pages        = {251--268},
  publisher    = {Elsevier},
  series       = {International Review of Neurobiology},
  title        = {Mechanisms underlying the end-to-side nerve regeneration},
  url          = {http://dx.doi.org/10.1016/S0074-7742(09)87012-8},
  volume       = {87},
  year         = {2009},
}