Mechanisms underlying the end-to-side nerve regeneration
Bontioti, Eleana LU and Dahlin, Lars LU
(2009)
In International Review of Neurobiology
87.
p.251-268
- Abstract
- End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and terminal regenerating sprouting from the donor nerve. A variety of experimental models, most commonly in the lower and upper extremity of rats, and techniques have been used to shed light on the mechanisms. Retrograde labeling techniques have revealed that collateral sprouting do occur, but is probably, at least as observed in long-term experiments,... (More)
- End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and terminal regenerating sprouting from the donor nerve. A variety of experimental models, most commonly in the lower and upper extremity of rats, and techniques have been used to shed light on the mechanisms. Retrograde labeling techniques have revealed that collateral sprouting do occur, but is probably, at least as observed in long-term experiments, less important over time. Pruning of branching nerve fibers, induced by the collateral sprouting, is an additional mechanism in this context. Experiments have also focused on the stimuli, including the question of epineurial or perineurial windows, that trigger the sprouting of axons form the donor nerve, which can detected by the use of markers of cellular injury. In die present article, we review studies contributing to clarifications of mechanisms of end-to-side nerve repair, including used experimental techniques. We also stress the importance of the plastic brain. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1492377
- author
- Bontioti, Eleana
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Review of Neurobiology
- volume
- 87
- pages
- 251 - 268
- publisher
- Elsevier
- external identifiers
-
- wos:000269657600012
- scopus:70349784421
- ISSN
- 0074-7742
- DOI
- 10.1016/S0074-7742(09)87012-8
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Hand Surgery Research Group (013241910)
- id
- 55796f7a-a290-4e96-b845-e0fe1283836b (old id 1492377)
- date added to LUP
- 2016-04-01 14:06:52
- date last changed
- 2022-01-27 22:50:14
@article{55796f7a-a290-4e96-b845-e0fe1283836b,
abstract = {{End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and terminal regenerating sprouting from the donor nerve. A variety of experimental models, most commonly in the lower and upper extremity of rats, and techniques have been used to shed light on the mechanisms. Retrograde labeling techniques have revealed that collateral sprouting do occur, but is probably, at least as observed in long-term experiments, less important over time. Pruning of branching nerve fibers, induced by the collateral sprouting, is an additional mechanism in this context. Experiments have also focused on the stimuli, including the question of epineurial or perineurial windows, that trigger the sprouting of axons form the donor nerve, which can detected by the use of markers of cellular injury. In die present article, we review studies contributing to clarifications of mechanisms of end-to-side nerve repair, including used experimental techniques. We also stress the importance of the plastic brain.}},
author = {{Bontioti, Eleana and Dahlin, Lars}},
issn = {{0074-7742}},
language = {{eng}},
pages = {{251--268}},
publisher = {{Elsevier}},
series = {{International Review of Neurobiology}},
title = {{Mechanisms underlying the end-to-side nerve regeneration}},
url = {{http://dx.doi.org/10.1016/S0074-7742(09)87012-8}},
doi = {{10.1016/S0074-7742(09)87012-8}},
volume = {{87}},
year = {{2009}},
}