Impact of chemotherapy regimen and rituximab in adult Burkitt lymphoma: a retrospective population-based study from the Nordic Lymphoma Group.
(2013) In Annals of Oncology 24(7). p.1879-1886- Abstract
- BackgroundStandard treatment of adult Burkitt lymphoma is not defined due to the lack of randomised trials. In this situation, population-based data may represent a useful contribution in order to identify an optimal treatment strategy.Patients and methodsThe aims of this study were to investigate the outcome for adult HIV-negative BL with different chemotherapy regimens, and to assess possible improvement within the time frame of the study. The study population was identified through the Swedish and Danish lymphoma registries 2000-2009.ResultsA total of 258 patients were identified. Since 2000, overall survival (OS) improved significantly only for younger patients (<65 years). Intensive regimens such as the Berlin-Frankfurt-Münster,... (More)
- BackgroundStandard treatment of adult Burkitt lymphoma is not defined due to the lack of randomised trials. In this situation, population-based data may represent a useful contribution in order to identify an optimal treatment strategy.Patients and methodsThe aims of this study were to investigate the outcome for adult HIV-negative BL with different chemotherapy regimens, and to assess possible improvement within the time frame of the study. The study population was identified through the Swedish and Danish lymphoma registries 2000-2009.ResultsA total of 258 patients were identified. Since 2000, overall survival (OS) improved significantly only for younger patients (<65 years). Intensive regimens such as the Berlin-Frankfurt-Münster, hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) and cyclophosphamide, vincristine, doxorubicin, methotrexate, ifosfamide, etoposide, and cytarabine (CODOX-M/IVAC) were associated with a favourable 2-year OS of 82%, 83%, and 69%, respectively. The low-intensive CHOP/CHOEP regimens achieved a 2-year OS of 38.8%, confirming their inadequacy for the treatment of BL. In a multivariate analysis, rituximab was not significantly associated with improved OS.ConclusionsIn this population-based retrospective series of adult BL, intensive chemotherapy regimens were associated with favourable outcome. The impact of the addition of rituximab remains uncertain and warrants further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3628801
- author
- Wästerlid, Tove LU ; Brown, P N ; Hagberg, Oskar LU ; Hagberg, H ; Pedersen, L M ; D'Amore, F and Jerkeman, Mats LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Oncology
- volume
- 24
- issue
- 7
- pages
- 1879 - 1886
- publisher
- Oxford University Press
- external identifiers
-
- wos:000321881600025
- pmid:23446093
- scopus:84883751931
- pmid:23446093
- ISSN
- 1569-8041
- DOI
- 10.1093/annonc/mdt058
- language
- English
- LU publication?
- yes
- id
- 14fb3fb4-6b7a-42d7-9d17-1805793f1f33 (old id 3628801)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23446093?dopt=Abstract
- date added to LUP
- 2016-04-01 10:03:25
- date last changed
- 2022-03-19 08:54:26
@article{14fb3fb4-6b7a-42d7-9d17-1805793f1f33, abstract = {{BackgroundStandard treatment of adult Burkitt lymphoma is not defined due to the lack of randomised trials. In this situation, population-based data may represent a useful contribution in order to identify an optimal treatment strategy.Patients and methodsThe aims of this study were to investigate the outcome for adult HIV-negative BL with different chemotherapy regimens, and to assess possible improvement within the time frame of the study. The study population was identified through the Swedish and Danish lymphoma registries 2000-2009.ResultsA total of 258 patients were identified. Since 2000, overall survival (OS) improved significantly only for younger patients (<65 years). Intensive regimens such as the Berlin-Frankfurt-Münster, hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) and cyclophosphamide, vincristine, doxorubicin, methotrexate, ifosfamide, etoposide, and cytarabine (CODOX-M/IVAC) were associated with a favourable 2-year OS of 82%, 83%, and 69%, respectively. The low-intensive CHOP/CHOEP regimens achieved a 2-year OS of 38.8%, confirming their inadequacy for the treatment of BL. In a multivariate analysis, rituximab was not significantly associated with improved OS.ConclusionsIn this population-based retrospective series of adult BL, intensive chemotherapy regimens were associated with favourable outcome. The impact of the addition of rituximab remains uncertain and warrants further investigation.}}, author = {{Wästerlid, Tove and Brown, P N and Hagberg, Oskar and Hagberg, H and Pedersen, L M and D'Amore, F and Jerkeman, Mats}}, issn = {{1569-8041}}, language = {{eng}}, number = {{7}}, pages = {{1879--1886}}, publisher = {{Oxford University Press}}, series = {{Annals of Oncology}}, title = {{Impact of chemotherapy regimen and rituximab in adult Burkitt lymphoma: a retrospective population-based study from the Nordic Lymphoma Group.}}, url = {{https://lup.lub.lu.se/search/files/1520861/3812607.pdf}}, doi = {{10.1093/annonc/mdt058}}, volume = {{24}}, year = {{2013}}, }