Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men.
(2009) In The Journal of clinical endocrinology and metabolism 94. p.5078-5084- Abstract
- Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression... (More)
- Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1500111
- author
- Movérare-Skrtic, Sofia ; Svensson, Johan ; Karlsson, Magnus LU ; Orwoll, Eric ; Ljunggren, Osten ; Mellström, Dan and Ohlsson, Claes
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 94
- pages
- 5078 - 5084
- publisher
- Oxford University Press
- external identifiers
-
- wos:000272379400063
- pmid:19846733
- scopus:73249128862
- pmid:19846733
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2009-1450
- language
- English
- LU publication?
- yes
- id
- f1d15ad7-3a18-4002-b74b-9ab97605191a (old id 1500111)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19846733?dopt=Abstract
- date added to LUP
- 2016-04-04 09:12:32
- date last changed
- 2024-02-28 00:18:51
@article{f1d15ad7-3a18-4002-b74b-9ab97605191a, abstract = {{Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. Results: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. Conclusions: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined.}}, author = {{Movérare-Skrtic, Sofia and Svensson, Johan and Karlsson, Magnus and Orwoll, Eric and Ljunggren, Osten and Mellström, Dan and Ohlsson, Claes}}, issn = {{1945-7197}}, language = {{eng}}, pages = {{5078--5084}}, publisher = {{Oxford University Press}}, series = {{The Journal of clinical endocrinology and metabolism}}, title = {{Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men.}}, url = {{http://dx.doi.org/10.1210/jc.2009-1450}}, doi = {{10.1210/jc.2009-1450}}, volume = {{94}}, year = {{2009}}, }