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Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.

Groop, Leif LU ; Segerlantz, Mikael LU and Bramnert, Margareta LU (2005) In Hormone Research 64 Suppl 3(Suppl 3). p.45-50
Abstract
Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not... (More)
Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insulin sensitivity, adults, growth hormone, treatment, growth hormone deficiency
in
Hormone Research
volume
64 Suppl 3
issue
Suppl 3
pages
45 - 50
publisher
Karger
external identifiers
  • wos:000235194200008
  • scopus:31544438039
ISSN
0301-0163
DOI
10.1159/000089317
language
English
LU publication?
yes
id
17e42f4c-195c-4fc7-9a1d-73fe501bcbc3 (old id 150077)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16439844&dopt=Abstract
date added to LUP
2007-07-23 09:54:17
date last changed
2017-01-01 07:19:24
@article{17e42f4c-195c-4fc7-9a1d-73fe501bcbc3,
  abstract     = {Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.},
  author       = {Groop, Leif and Segerlantz, Mikael and Bramnert, Margareta},
  issn         = {0301-0163},
  keyword      = {insulin sensitivity,adults,growth hormone,treatment,growth hormone deficiency},
  language     = {eng},
  number       = {Suppl 3},
  pages        = {45--50},
  publisher    = {Karger},
  series       = {Hormone Research},
  title        = {Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.},
  url          = {http://dx.doi.org/10.1159/000089317},
  volume       = {64 Suppl 3},
  year         = {2005},
}