Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa.
Mohammad, Aladdin LU ; Jacobsson, Lennart LU ; Westman, Kerstin LU ; Sturfelt, Gunnar LU and Segelmark, Mårten LU
(2009)
In Rheumatology (Oxford, England)
48.
p.1560-1565
- Abstract
- Objective. To estimate the incidence of and survival rates for WG, microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS) and PAN within a defined population in southern Sweden. Methods. Cases were retrieved using hospital records and a serology database. All new cases of WG, MPA, CSS and PAN between 1997 and 2006 were included, provided they met pre-defined criteria, and were followed until 30 June 2008. The study area comprised two health care districts with a total population of 641 000. The standardized mortality ratio (SMR) was estimated using Swedish population data as a reference. Results. A total of 140 (WG, 63; MPA 65; CSS 6; and PAN 6) cases (52% women) with a median age of 67.6 (range 20-96) years fulfilled the inclusion... (More)
- Objective. To estimate the incidence of and survival rates for WG, microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS) and PAN within a defined population in southern Sweden. Methods. Cases were retrieved using hospital records and a serology database. All new cases of WG, MPA, CSS and PAN between 1997 and 2006 were included, provided they met pre-defined criteria, and were followed until 30 June 2008. The study area comprised two health care districts with a total population of 641 000. The standardized mortality ratio (SMR) was estimated using Swedish population data as a reference. Results. A total of 140 (WG, 63; MPA 65; CSS 6; and PAN 6) cases (52% women) with a median age of 67.6 (range 20-96) years fulfilled the inclusion criteria. The annual incidence per million of the population (95% CI) was estimated to be 9.8 (7.4-12.2) for WG, 10.1 (7.7-12.6) for MPA and 0.9 (0-1.7) for both CSS and PAN. The highest incidence was found in patients aged >/=75 years (79.1/million). The 1- and 5-year survival rates were 87.8 and 71.6% for all patients, but lower for MPA (80 and 55%) compared with WG (95 and 83%; P = 0.001), although the difference was not significant in the multivariate analysis. The SMR was 2.77 (95% CI 2.02, 3.71) for all patients. Conclusions. The incidence of WG and MPA was equal in our district, but there was a difference in survival rates related to age and renal function. A progressive increase in age-specific incidence rates was observed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1500770
- author
- Mohammad, Aladdin
LU
; Jacobsson, Lennart
LU
; Westman, Kerstin
LU
; Sturfelt, Gunnar
LU
and Segelmark, Mårten
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Rheumatology (Oxford, England)
- volume
- 48
- pages
- 1560 - 1565
- publisher
- Oxford University Press
- external identifiers
-
- wos:000272081000022
- pmid:19797309
- scopus:75649143613
- pmid:19797309
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/kep304
- language
- English
- LU publication?
- yes
- id
- 1fae298b-44fa-4ebc-bca0-ce44cdc340f2 (old id 1500770)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19797309?dopt=Abstract
- http://rheumatology.oxfordjournals.org/content/48/12/1560.short
- date added to LUP
- 2016-04-04 09:21:19
- date last changed
- 2024-10-28 00:21:24
@article{1fae298b-44fa-4ebc-bca0-ce44cdc340f2,
abstract = {{Objective. To estimate the incidence of and survival rates for WG, microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS) and PAN within a defined population in southern Sweden. Methods. Cases were retrieved using hospital records and a serology database. All new cases of WG, MPA, CSS and PAN between 1997 and 2006 were included, provided they met pre-defined criteria, and were followed until 30 June 2008. The study area comprised two health care districts with a total population of 641 000. The standardized mortality ratio (SMR) was estimated using Swedish population data as a reference. Results. A total of 140 (WG, 63; MPA 65; CSS 6; and PAN 6) cases (52% women) with a median age of 67.6 (range 20-96) years fulfilled the inclusion criteria. The annual incidence per million of the population (95% CI) was estimated to be 9.8 (7.4-12.2) for WG, 10.1 (7.7-12.6) for MPA and 0.9 (0-1.7) for both CSS and PAN. The highest incidence was found in patients aged >/=75 years (79.1/million). The 1- and 5-year survival rates were 87.8 and 71.6% for all patients, but lower for MPA (80 and 55%) compared with WG (95 and 83%; P = 0.001), although the difference was not significant in the multivariate analysis. The SMR was 2.77 (95% CI 2.02, 3.71) for all patients. Conclusions. The incidence of WG and MPA was equal in our district, but there was a difference in survival rates related to age and renal function. A progressive increase in age-specific incidence rates was observed.}},
author = {{Mohammad, Aladdin and Jacobsson, Lennart and Westman, Kerstin and Sturfelt, Gunnar and Segelmark, Mårten}},
issn = {{1462-0332}},
language = {{eng}},
pages = {{1560--1565}},
publisher = {{Oxford University Press}},
series = {{Rheumatology (Oxford, England)}},
title = {{Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa.}},
url = {{http://dx.doi.org/10.1093/rheumatology/kep304}},
doi = {{10.1093/rheumatology/kep304}},
volume = {{48}},
year = {{2009}},
}