Registration of serial SPECT/CT images for three-dimensional dosimetry in radionuclide therapy.
(2009) In Physics in Medicine and Biology 54(20). p.6181-6200- Abstract
- For radionuclide therapy, individual patient pharmacokinetics can be measured in three dimensions by sequential SPECT imaging. Accurate registration of the time series of images is central for voxel-based calculations of the residence time and absorbed dose. In this work, rigid and non-rigid methods are evaluated for registration of 6-7 SPECT/CT images acquired over a week, in anatomical regions from the head-and-neck region down to the pelvis. A method for calculation of the absorbed dose, including a voxel mass determination from the CT images, is also described. Registration of the SPECT/CT images is based on a CT-derived spatial transformation. Evaluation is focused on the CT registration accuracy, and on its impact on values of... (More)
- For radionuclide therapy, individual patient pharmacokinetics can be measured in three dimensions by sequential SPECT imaging. Accurate registration of the time series of images is central for voxel-based calculations of the residence time and absorbed dose. In this work, rigid and non-rigid methods are evaluated for registration of 6-7 SPECT/CT images acquired over a week, in anatomical regions from the head-and-neck region down to the pelvis. A method for calculation of the absorbed dose, including a voxel mass determination from the CT images, is also described. Registration of the SPECT/CT images is based on a CT-derived spatial transformation. Evaluation is focused on the CT registration accuracy, and on its impact on values of residence time and absorbed dose. According to the CT evaluation, the non-rigid method produces a more accurate registration than the rigid one. For images of the residence time and absorbed dose, registration produces a sharpening of the images. For volumes-of-interest, the differences between rigid and non-rigid results are generally small. However, the non-rigid method is more consistent for regions where non-rigid patient movements are likely, such as in the head-neck-shoulder region. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1500858
- author
- Sjögreen Gleisner, Katarina LU ; Rueckert, David and Ljungberg, Michael LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 54
- issue
- 20
- pages
- 6181 - 6200
- publisher
- IOP Publishing
- external identifiers
-
- wos:000270563300010
- pmid:19794243
- scopus:70449113256
- pmid:19794243
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/54/20/010
- language
- English
- LU publication?
- yes
- id
- bd2a7cc6-0f12-4e06-b9a1-1c5f877bcce1 (old id 1500858)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19794243?dopt=Abstract
- date added to LUP
- 2016-04-04 07:23:15
- date last changed
- 2022-03-30 22:13:07
@article{bd2a7cc6-0f12-4e06-b9a1-1c5f877bcce1,
abstract = {{For radionuclide therapy, individual patient pharmacokinetics can be measured in three dimensions by sequential SPECT imaging. Accurate registration of the time series of images is central for voxel-based calculations of the residence time and absorbed dose. In this work, rigid and non-rigid methods are evaluated for registration of 6-7 SPECT/CT images acquired over a week, in anatomical regions from the head-and-neck region down to the pelvis. A method for calculation of the absorbed dose, including a voxel mass determination from the CT images, is also described. Registration of the SPECT/CT images is based on a CT-derived spatial transformation. Evaluation is focused on the CT registration accuracy, and on its impact on values of residence time and absorbed dose. According to the CT evaluation, the non-rigid method produces a more accurate registration than the rigid one. For images of the residence time and absorbed dose, registration produces a sharpening of the images. For volumes-of-interest, the differences between rigid and non-rigid results are generally small. However, the non-rigid method is more consistent for regions where non-rigid patient movements are likely, such as in the head-neck-shoulder region.}},
author = {{Sjögreen Gleisner, Katarina and Rueckert, David and Ljungberg, Michael}},
issn = {{1361-6560}},
language = {{eng}},
number = {{20}},
pages = {{6181--6200}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{Registration of serial SPECT/CT images for three-dimensional dosimetry in radionuclide therapy.}},
url = {{http://dx.doi.org/10.1088/0031-9155/54/20/010}},
doi = {{10.1088/0031-9155/54/20/010}},
volume = {{54}},
year = {{2009}},
}