Successful treatment of a child with t(15;19)-positive tumor.
(2007) In Pediatric Blood & Cancer 49. p.1015-1017- Abstract
- A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric... (More)
- A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation. More importantly, our results also demonstrate that at least some patients with t(15;19)-positive tumors may be successfully treated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/150128
- author
- Mertens, Fredrik LU ; Wiebe, Thomas LU ; Adlercreutz, Catharina ; Mandahl, Nils LU and French, Christopher A
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chemotherapy, Ewing tumor, NUT, t(15, 19), BRD4
- in
- Pediatric Blood & Cancer
- volume
- 49
- pages
- 1015 - 1017
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000250487800030
- scopus:35648989427
- ISSN
- 1545-5017
- DOI
- 10.1002/pbc.20755
- language
- English
- LU publication?
- yes
- id
- 6d9f8103-8bad-4245-a3f2-f6bca6f70100 (old id 150128)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16435379&dopt=Abstract
- date added to LUP
- 2016-04-01 12:31:01
- date last changed
- 2022-03-13 19:00:16
@article{6d9f8103-8bad-4245-a3f2-f6bca6f70100, abstract = {{A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation. More importantly, our results also demonstrate that at least some patients with t(15;19)-positive tumors may be successfully treated.}}, author = {{Mertens, Fredrik and Wiebe, Thomas and Adlercreutz, Catharina and Mandahl, Nils and French, Christopher A}}, issn = {{1545-5017}}, keywords = {{chemotherapy; Ewing tumor; NUT; t(15; 19); BRD4}}, language = {{eng}}, pages = {{1015--1017}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Pediatric Blood & Cancer}}, title = {{Successful treatment of a child with t(15;19)-positive tumor.}}, url = {{http://dx.doi.org/10.1002/pbc.20755}}, doi = {{10.1002/pbc.20755}}, volume = {{49}}, year = {{2007}}, }