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Successful treatment of a child with t(15;19)-positive tumor.

Mertens, Fredrik LU ; Wiebe, Thomas LU ; Adlercreutz, Catharina; Mandahl, Nils LU and French, Christopher A (2007) In Pediatric Blood & Cancer 49. p.1015-1017
Abstract
A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric... (More)
A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation. More importantly, our results also demonstrate that at least some patients with t(15;19)-positive tumors may be successfully treated. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chemotherapy, Ewing tumor, NUT, t(15, 19), BRD4
in
Pediatric Blood & Cancer
volume
49
pages
1015 - 1017
publisher
John Wiley and Sons Inc.
external identifiers
  • wos:000250487800030
  • scopus:35648989427
ISSN
1545-5017
DOI
10.1002/pbc.20755
language
English
LU publication?
yes
id
6d9f8103-8bad-4245-a3f2-f6bca6f70100 (old id 150128)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16435379&dopt=Abstract
date added to LUP
2007-07-08 12:57:30
date last changed
2017-10-29 03:42:54
@article{6d9f8103-8bad-4245-a3f2-f6bca6f70100,
  abstract     = {A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation. More importantly, our results also demonstrate that at least some patients with t(15;19)-positive tumors may be successfully treated.},
  author       = {Mertens, Fredrik and Wiebe, Thomas and Adlercreutz, Catharina and Mandahl, Nils and French, Christopher A},
  issn         = {1545-5017},
  keyword      = {chemotherapy,Ewing tumor,NUT,t(15,19),BRD4},
  language     = {eng},
  pages        = {1015--1017},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Pediatric Blood & Cancer},
  title        = {Successful treatment of a child with t(15;19)-positive tumor.},
  url          = {http://dx.doi.org/10.1002/pbc.20755},
  volume       = {49},
  year         = {2007},
}