Lentiviral Vectors for Use in the Central Nervous System.
Jakobsson, Johan LU
and Lundberg, Cecilia
LU
(2006)
In Molecular Therapy
13(3).
p.484-493
- Abstract
- Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/150432
- author
- Jakobsson, Johan
LU
and Lundberg, Cecilia
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- neurological disorders, brain, lentivirus, gene therapy, siRNA, Tet system
- in
- Molecular Therapy
- volume
- 13
- issue
- 3
- pages
- 484 - 493
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000236445000004
- scopus:32944473438
- ISSN
- 1525-0024
- DOI
- 10.1016/j.ymthe.2005.11.012
- language
- English
- LU publication?
- yes
- id
- 44ff6544-2df8-4a96-a839-fc9a918663ad (old id 150432)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16403676&dopt=Abstract
- date added to LUP
- 2016-04-01 12:06:12
- date last changed
- 2022-04-29 00:39:48
@article{44ff6544-2df8-4a96-a839-fc9a918663ad,
abstract = {{Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.}},
author = {{Jakobsson, Johan and Lundberg, Cecilia}},
issn = {{1525-0024}},
keywords = {{neurological disorders; brain; lentivirus; gene therapy; siRNA; Tet system}},
language = {{eng}},
number = {{3}},
pages = {{484--493}},
publisher = {{Nature Publishing Group}},
series = {{Molecular Therapy}},
title = {{Lentiviral Vectors for Use in the Central Nervous System.}},
url = {{http://dx.doi.org/10.1016/j.ymthe.2005.11.012}},
doi = {{10.1016/j.ymthe.2005.11.012}},
volume = {{13}},
year = {{2006}},
}