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Lentiviral Vectors for Use in the Central Nervous System.

Jakobsson, Johan LU orcid and Lundberg, Cecilia LU orcid (2006) In Molecular Therapy 13(3). p.484-493
Abstract
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurological disorders, brain, lentivirus, gene therapy, siRNA, Tet system
in
Molecular Therapy
volume
13
issue
3
pages
484 - 493
publisher
Nature Publishing Group
external identifiers
  • wos:000236445000004
  • scopus:32944473438
ISSN
1525-0024
DOI
10.1016/j.ymthe.2005.11.012
language
English
LU publication?
yes
id
44ff6544-2df8-4a96-a839-fc9a918663ad (old id 150432)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16403676&dopt=Abstract
date added to LUP
2016-04-01 12:06:12
date last changed
2020-08-05 01:55:15
@article{44ff6544-2df8-4a96-a839-fc9a918663ad,
  abstract     = {Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.},
  author       = {Jakobsson, Johan and Lundberg, Cecilia},
  issn         = {1525-0024},
  language     = {eng},
  number       = {3},
  pages        = {484--493},
  publisher    = {Nature Publishing Group},
  series       = {Molecular Therapy},
  title        = {Lentiviral Vectors for Use in the Central Nervous System.},
  url          = {http://dx.doi.org/10.1016/j.ymthe.2005.11.012},
  doi          = {10.1016/j.ymthe.2005.11.012},
  volume       = {13},
  year         = {2006},
}