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Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients

Hemminki, Kari; Sundquist, Jan LU and Bermejo, Justo L. (2009) In British Journal of Haematology 147(4). p.526-530
Abstract
Polycythaemia vera (PV) and primary myelofibrosis (MF) show concordant familial clustering but limited population level data are available on the aggregation of other discordant neoplasms in these families. We used the Swedish Family-Cancer Database to assess risks for VP and MF in families of cancer patients. A total of 3530 first PV and 1606 MF patients were identified, with high concordant familial risks. Several discordant familial associations were found for PV (acute myeloid leukaemia, Hodgkin disease, prostate and bladder cancers) or for MF (chronic lymphatic leukaemia, colorectal, kidney and cervical cancers) or for both (nervous system, eye and endocrine tumours).
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
family history, leukaemia, polycythaemia vera, myelofibrosis, discordant cancers
in
British Journal of Haematology
volume
147
issue
4
pages
526 - 530
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000271240900011
  • scopus:70350451750
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2009.07874.x
language
English
LU publication?
yes
id
5b2d2695-532f-4226-a47c-24b234baca7c (old id 1505176)
date added to LUP
2009-11-24 14:11:54
date last changed
2017-01-01 04:50:58
@article{5b2d2695-532f-4226-a47c-24b234baca7c,
  abstract     = {Polycythaemia vera (PV) and primary myelofibrosis (MF) show concordant familial clustering but limited population level data are available on the aggregation of other discordant neoplasms in these families. We used the Swedish Family-Cancer Database to assess risks for VP and MF in families of cancer patients. A total of 3530 first PV and 1606 MF patients were identified, with high concordant familial risks. Several discordant familial associations were found for PV (acute myeloid leukaemia, Hodgkin disease, prostate and bladder cancers) or for MF (chronic lymphatic leukaemia, colorectal, kidney and cervical cancers) or for both (nervous system, eye and endocrine tumours).},
  author       = {Hemminki, Kari and Sundquist, Jan and Bermejo, Justo L.},
  issn         = {0007-1048},
  keyword      = {family history,leukaemia,polycythaemia vera,myelofibrosis,discordant cancers},
  language     = {eng},
  number       = {4},
  pages        = {526--530},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2009.07874.x},
  volume       = {147},
  year         = {2009},
}