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Dimethylsulfoxide-soluble Smoking Particles and Nicotine Affect Vascular Contractibility

Zhang, Jin-Yan; Cao, Lei; Zheng, Xiao-Hui; Xu, Cang-Bao LU and Cao, Yong-Xiao (2009) In Archives of Pharmacal Research 32(10). p.1475-1481
Abstract
The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP 0.4 mL/L and nicotine 0.48 and 0.96 mg/L shifted the concentration-contractile curves induced by sarafotoxin 6c, a selective agonist for ETB receptor toward the left with increased E-max. DSP 0.4 mL/L and nicotine 0.96 mg/L shifted ETA receptor-mediated the concentration-contractile curves toward the left with increased E-max. However, nicotine 0.06 mg/L which is the equivalent concentration of nicotine in DSP 0.4 mL/L did not affect the curves and... (More)
The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP 0.4 mL/L and nicotine 0.48 and 0.96 mg/L shifted the concentration-contractile curves induced by sarafotoxin 6c, a selective agonist for ETB receptor toward the left with increased E-max. DSP 0.4 mL/L and nicotine 0.96 mg/L shifted ETA receptor-mediated the concentration-contractile curves toward the left with increased E-max. However, nicotine 0.06 mg/L which is the equivalent concentration of nicotine in DSP 0.4 mL/L did not affect the curves and the E-max mediated with ETA receptor and ETB receptor. DSP 0.2 and 0.4 mL/L shifted the concentration-contractile curves induced by noradrenaline toward the right with decreased E-max. Neither did nicotine 0.06 and 0.96 mg/L. Both DSP and nicotine shifted the concentration-contractile curves induced by 5-hydroxytryptamine (5-HT) toward the right parallely. DSP changed the phenotypes towards an increased efficacy of ETA receptor and ETB receptor, and a reduced efficacy of 5-HT receptor and alpha-adrenocceptor. The effects of DSP on ETB receptor, ETA receptor and alpha-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
artery, Mesenteric, Dimethylsulfoxide-soluble smoking particles, Nicotine, Receptor, Vascular contraction
in
Archives of Pharmacal Research
volume
32
issue
10
pages
1475 - 1481
publisher
Pharmaceutical Society of Korea
external identifiers
  • wos:000271237100021
  • scopus:70450175131
ISSN
1976-3786
DOI
10.1007/s12272-009-2019-y
language
English
LU publication?
yes
id
6fb6d2b3-743c-44d8-a6eb-68cc9f779cd4 (old id 1505216)
date added to LUP
2009-11-24 13:47:26
date last changed
2017-02-26 03:27:22
@article{6fb6d2b3-743c-44d8-a6eb-68cc9f779cd4,
  abstract     = {The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP 0.4 mL/L and nicotine 0.48 and 0.96 mg/L shifted the concentration-contractile curves induced by sarafotoxin 6c, a selective agonist for ETB receptor toward the left with increased E-max. DSP 0.4 mL/L and nicotine 0.96 mg/L shifted ETA receptor-mediated the concentration-contractile curves toward the left with increased E-max. However, nicotine 0.06 mg/L which is the equivalent concentration of nicotine in DSP 0.4 mL/L did not affect the curves and the E-max mediated with ETA receptor and ETB receptor. DSP 0.2 and 0.4 mL/L shifted the concentration-contractile curves induced by noradrenaline toward the right with decreased E-max. Neither did nicotine 0.06 and 0.96 mg/L. Both DSP and nicotine shifted the concentration-contractile curves induced by 5-hydroxytryptamine (5-HT) toward the right parallely. DSP changed the phenotypes towards an increased efficacy of ETA receptor and ETB receptor, and a reduced efficacy of 5-HT receptor and alpha-adrenocceptor. The effects of DSP on ETB receptor, ETA receptor and alpha-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine.},
  author       = {Zhang, Jin-Yan and Cao, Lei and Zheng, Xiao-Hui and Xu, Cang-Bao and Cao, Yong-Xiao},
  issn         = {1976-3786},
  keyword      = {artery,Mesenteric,Dimethylsulfoxide-soluble smoking particles,Nicotine,Receptor,Vascular contraction},
  language     = {eng},
  number       = {10},
  pages        = {1475--1481},
  publisher    = {Pharmaceutical Society of Korea},
  series       = {Archives of Pharmacal Research},
  title        = {Dimethylsulfoxide-soluble Smoking Particles and Nicotine Affect Vascular Contractibility},
  url          = {http://dx.doi.org/10.1007/s12272-009-2019-y},
  volume       = {32},
  year         = {2009},
}