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The Survival of Memory CD4(+) T Cells within the Gut Lamina Propria Requires OX40 and CD30 Signals

Withers, David R.; Jaensson Gyllenbäck, Elin LU ; Gaspal, Fabrina; McConnell, Fiona M.; Eksteen, Bertus; Anderson, Graham; Agace, William LU and Lane, Peter J. L. (2009) In Journal of Immunology 183(8). p.5079-5084
Abstract
Although CD4(+) memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria. Deficiency in either CD30 or OX40 alone reduced CD4(+) T cell numbers, however, in mice deficient in both OX40 and CD30, CD4(+) T cell loss was greatly exacerbated. This loss of CD4(+) T cells was not due to a homing defect because CD30 x OX40-deficient OTH cells were not impaired in their ability to express CCR9 and alpha(4)beta(7) or traffic to the small intestine. There was also no difference in the priming of wild-type (WT) and CD30... (More)
Although CD4(+) memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria. Deficiency in either CD30 or OX40 alone reduced CD4(+) T cell numbers, however, in mice deficient in both OX40 and CD30, CD4(+) T cell loss was greatly exacerbated. This loss of CD4(+) T cells was not due to a homing defect because CD30 x OX40-deficient OTH cells were not impaired in their ability to express CCR9 and alpha(4)beta(7) or traffic to the small intestine. There was also no difference in the priming of wild-type (WT) and CD30 x OX40-deficient OTH cells in the mesenteric lymph node after oral immunization. However, following oral immunization, CD30 x OX40-deficient OTH cells trafficked to the lamina propria but failed to persist compared with WT OTH cells. This was not due to reduced levels of Bcl-2 or Bcl-XL, because expression of these was comparable between wT and double knockout OTH cells. Collectively, these data demonstrate that signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria. The Journal of Immunology, 2009, 183: 5079-5084. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
183
issue
8
pages
5079 - 5084
publisher
American Association of Immunologists
external identifiers
  • wos:000270830300033
  • scopus:77954116318
ISSN
1550-6606
DOI
10.4049/jimmunol.0901514
language
English
LU publication?
yes
id
a8d58dba-e720-4ddd-949f-9feef5f7514b (old id 1506287)
date added to LUP
2009-11-23 16:06:11
date last changed
2017-10-29 03:53:04
@article{a8d58dba-e720-4ddd-949f-9feef5f7514b,
  abstract     = {Although CD4(+) memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria. Deficiency in either CD30 or OX40 alone reduced CD4(+) T cell numbers, however, in mice deficient in both OX40 and CD30, CD4(+) T cell loss was greatly exacerbated. This loss of CD4(+) T cells was not due to a homing defect because CD30 x OX40-deficient OTH cells were not impaired in their ability to express CCR9 and alpha(4)beta(7) or traffic to the small intestine. There was also no difference in the priming of wild-type (WT) and CD30 x OX40-deficient OTH cells in the mesenteric lymph node after oral immunization. However, following oral immunization, CD30 x OX40-deficient OTH cells trafficked to the lamina propria but failed to persist compared with WT OTH cells. This was not due to reduced levels of Bcl-2 or Bcl-XL, because expression of these was comparable between wT and double knockout OTH cells. Collectively, these data demonstrate that signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria. The Journal of Immunology, 2009, 183: 5079-5084.},
  author       = {Withers, David R. and Jaensson Gyllenbäck, Elin and Gaspal, Fabrina and McConnell, Fiona M. and Eksteen, Bertus and Anderson, Graham and Agace, William and Lane, Peter J. L.},
  issn         = {1550-6606},
  language     = {eng},
  number       = {8},
  pages        = {5079--5084},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {The Survival of Memory CD4(+) T Cells within the Gut Lamina Propria Requires OX40 and CD30 Signals},
  url          = {http://dx.doi.org/10.4049/jimmunol.0901514},
  volume       = {183},
  year         = {2009},
}