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Does Longstanding Nicotine Exposure Impair Bone Healing and Osseointegration? An Experimental Study in Rabbits

Gotfredsen, Klaus ; Lindh, Christian LU orcid and Berglundh, Tord (2009) In Journal of Biomedical Materials Research. Part B - Applied Biomaterials 91B(2). p.918-923
Abstract
Objectives: The aim of this study was to analyze the effect of longstanding nicotine exposure on bone healing and osseointegration of titanium implants. Materials and Methods: 20 female rabbits received either nicotine (n = 10) or saline (n = 10) administered subcutaneously via mini-osmotic pumps for 32 weeks. The pump delivered 6 mu g/kg/min of nicotine for the animals in the test group. Blood samples were collected and plasma cotinine levels were measured monthly. Six months after the commencement of nicotine or saline administration three osteotomy preparations, one in right, femoral condyle and two in the right tibia were made. One experimental implant was placed in the femur site and one in the most distal preparation of the tibia.... (More)
Objectives: The aim of this study was to analyze the effect of longstanding nicotine exposure on bone healing and osseointegration of titanium implants. Materials and Methods: 20 female rabbits received either nicotine (n = 10) or saline (n = 10) administered subcutaneously via mini-osmotic pumps for 32 weeks. The pump delivered 6 mu g/kg/min of nicotine for the animals in the test group. Blood samples were collected and plasma cotinine levels were measured monthly. Six months after the commencement of nicotine or saline administration three osteotomy preparations, one in right, femoral condyle and two in the right tibia were made. One experimental implant was placed in the femur site and one in the most distal preparation of the tibia. The remaining site in the tibia was left empty. The osteotomy preparation and implant installation procedure was repeated in the left leg of the rabbits after 2 weeks. The implants in the tibial site were subjected to removal torque test (RMT) 2 weeks later. Block biopsies of the two other osteotomy sites were prepared for histological analysis. Results: Although no differences in RMT values were found between test and control groups, there was a significant increase in RMT between 2 and 4 weeks within each group. The histomorphometric analysis of bone-to-implant contact and bone density in the bone defects revealed no differences between the test and the control group after 2 or 4 weeks of healing. Conclusion: Longstanding (6 months) nicotine exposure did not impair bone healing and osseointegration of titanium implants. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 91B: 918-923, 2009 (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
resonance frequency analysis, removal torque test, implants, bone healing, Smoking, nicotine, histomorphometry
in
Journal of Biomedical Materials Research. Part B - Applied Biomaterials
volume
91B
issue
2
pages
918 - 923
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000270868600050
  • scopus:71649112384
ISSN
1552-4981
DOI
10.1002/jbm.b.31475
language
English
LU publication?
yes
id
6b92bb05-032e-45ae-a40e-a317a902d897 (old id 1506315)
date added to LUP
2016-04-01 11:54:51
date last changed
2021-03-24 03:07:02
@article{6b92bb05-032e-45ae-a40e-a317a902d897,
  abstract     = {Objectives: The aim of this study was to analyze the effect of longstanding nicotine exposure on bone healing and osseointegration of titanium implants. Materials and Methods: 20 female rabbits received either nicotine (n = 10) or saline (n = 10) administered subcutaneously via mini-osmotic pumps for 32 weeks. The pump delivered 6 mu g/kg/min of nicotine for the animals in the test group. Blood samples were collected and plasma cotinine levels were measured monthly. Six months after the commencement of nicotine or saline administration three osteotomy preparations, one in right, femoral condyle and two in the right tibia were made. One experimental implant was placed in the femur site and one in the most distal preparation of the tibia. The remaining site in the tibia was left empty. The osteotomy preparation and implant installation procedure was repeated in the left leg of the rabbits after 2 weeks. The implants in the tibial site were subjected to removal torque test (RMT) 2 weeks later. Block biopsies of the two other osteotomy sites were prepared for histological analysis. Results: Although no differences in RMT values were found between test and control groups, there was a significant increase in RMT between 2 and 4 weeks within each group. The histomorphometric analysis of bone-to-implant contact and bone density in the bone defects revealed no differences between the test and the control group after 2 or 4 weeks of healing. Conclusion: Longstanding (6 months) nicotine exposure did not impair bone healing and osseointegration of titanium implants. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 91B: 918-923, 2009},
  author       = {Gotfredsen, Klaus and Lindh, Christian and Berglundh, Tord},
  issn         = {1552-4981},
  language     = {eng},
  number       = {2},
  pages        = {918--923},
  publisher    = {John Wiley & Sons Inc.},
  series       = {Journal of Biomedical Materials Research. Part B - Applied Biomaterials},
  title        = {Does Longstanding Nicotine Exposure Impair Bone Healing and Osseointegration? An Experimental Study in Rabbits},
  url          = {http://dx.doi.org/10.1002/jbm.b.31475},
  doi          = {10.1002/jbm.b.31475},
  volume       = {91B},
  year         = {2009},
}