Moraxella catarrhalis: from interactions with the host immune system to vaccine development.
(2012) In Future Microbiology 7(9). p.1073-1100- Abstract
- Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against... (More)
- Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against complement killing and host bactericidal molecules. Thus, breaking the basis of Moraxella immune evasion mechanisms is fundamental for future invention of effective therapy in controlling Moraxella infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3124241
- author
- Su, Yu-Ching LU ; Singh, Birendra LU and Riesbeck, Kristian LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Future Microbiology
- volume
- 7
- issue
- 9
- pages
- 1073 - 1100
- publisher
- Future Medicine Ltd.
- external identifiers
-
- wos:000308255500009
- pmid:22953708
- scopus:84866069938
- pmid:22953708
- ISSN
- 1746-0921
- DOI
- 10.2217/fmb.12.80
- language
- English
- LU publication?
- yes
- id
- 1509e778-5680-484d-b68c-27eb0a551631 (old id 3124241)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22953708?dopt=Abstract
- date added to LUP
- 2016-04-04 07:42:39
- date last changed
- 2022-05-16 20:25:10
@article{1509e778-5680-484d-b68c-27eb0a551631, abstract = {{Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against complement killing and host bactericidal molecules. Thus, breaking the basis of Moraxella immune evasion mechanisms is fundamental for future invention of effective therapy in controlling Moraxella infection.}}, author = {{Su, Yu-Ching and Singh, Birendra and Riesbeck, Kristian}}, issn = {{1746-0921}}, language = {{eng}}, number = {{9}}, pages = {{1073--1100}}, publisher = {{Future Medicine Ltd.}}, series = {{Future Microbiology}}, title = {{Moraxella catarrhalis: from interactions with the host immune system to vaccine development.}}, url = {{http://dx.doi.org/10.2217/fmb.12.80}}, doi = {{10.2217/fmb.12.80}}, volume = {{7}}, year = {{2012}}, }