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Plasma concentrations of apolipoproteins A-I, B, and M in patients with abdominal aortic aneurysms.

Ahnström, Josefin LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU (2010) In Clinical Biochemistry 43(4-5). p.407-410
Abstract
Objectives: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Design and methods: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. Results: AAA patients had lower apolipoprotein levels, as compared to healthy individuals; apoA-I, 1.62 vs. 2.08 g/l; apoB, 0.91 vs. 1.04 g/l; apoM, 0.72 vs. 0.91 mumol/l (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95%... (More)
Objectives: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Design and methods: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. Results: AAA patients had lower apolipoprotein levels, as compared to healthy individuals; apoA-I, 1.62 vs. 2.08 g/l; apoB, 0.91 vs. 1.04 g/l; apoM, 0.72 vs. 0.91 mumol/l (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively. Conclusions: ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AAA, ApoA-I, ApoB, Aneurysmal disease, Lipocalin, Lipoprotein, Apolipoprotein, HDL, ApoM, Signal peptide
in
Clinical Biochemistry
volume
43
issue
4-5
pages
407 - 410
publisher
Elsevier
external identifiers
  • wos:000275219400009
  • pmid:19932694
  • scopus:76749120943
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2009.11.006
language
English
LU publication?
yes
id
60690386-9793-4c49-b69a-738021488440 (old id 1511632)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19932694?dopt=Abstract
date added to LUP
2009-12-07 11:05:35
date last changed
2018-05-29 11:49:54
@article{60690386-9793-4c49-b69a-738021488440,
  abstract     = {Objectives: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Design and methods: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. Results: AAA patients had lower apolipoprotein levels, as compared to healthy individuals; apoA-I, 1.62 vs. 2.08 g/l; apoB, 0.91 vs. 1.04 g/l; apoM, 0.72 vs. 0.91 mumol/l (p&lt;0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively. Conclusions: ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA.},
  author       = {Ahnström, Josefin and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn},
  issn         = {1873-2933},
  keyword      = {AAA,ApoA-I,ApoB,Aneurysmal disease,Lipocalin,Lipoprotein,Apolipoprotein,HDL,ApoM,Signal peptide},
  language     = {eng},
  number       = {4-5},
  pages        = {407--410},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Plasma concentrations of apolipoproteins A-I, B, and M in patients with abdominal aortic aneurysms.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2009.11.006},
  volume       = {43},
  year         = {2010},
}