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Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase

Kempe, Maria LU and Mosbach, Klaus LU (1994) In Journal of Chromatography A 664(2). p.276-279
Abstract
A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Chromatography A
volume
664
issue
2
pages
276 - 279
publisher
Elsevier
external identifiers
  • scopus:0028196748
ISSN
0021-9673
DOI
10.1016/0021-9673(94)87016-0
language
English
LU publication?
yes
id
8bcd2020-84b6-4570-bdfa-e41082217ca3 (old id 1516062)
date added to LUP
2009-12-17 08:48:13
date last changed
2017-08-27 05:37:52
@article{8bcd2020-84b6-4570-bdfa-e41082217ca3,
  abstract     = {A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.},
  author       = {Kempe, Maria and Mosbach, Klaus},
  issn         = {0021-9673},
  language     = {eng},
  number       = {2},
  pages        = {276--279},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography A},
  title        = {Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase},
  url          = {http://dx.doi.org/10.1016/0021-9673(94)87016-0},
  volume       = {664},
  year         = {1994},
}