Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase
(1994) In Journal of Chromatography A 664(2). p.276-279- Abstract
- A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1516062
- author
- Kempe, Maria LU and Mosbach, Klaus LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Chromatography A
- volume
- 664
- issue
- 2
- pages
- 276 - 279
- publisher
- Elsevier
- external identifiers
-
- scopus:0028196748
- ISSN
- 0021-9673
- DOI
- 10.1016/0021-9673(94)87016-0
- language
- English
- LU publication?
- yes
- id
- 8bcd2020-84b6-4570-bdfa-e41082217ca3 (old id 1516062)
- date added to LUP
- 2016-04-01 17:02:57
- date last changed
- 2021-08-29 05:10:34
@article{8bcd2020-84b6-4570-bdfa-e41082217ca3, abstract = {{A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.}}, author = {{Kempe, Maria and Mosbach, Klaus}}, issn = {{0021-9673}}, language = {{eng}}, number = {{2}}, pages = {{276--279}}, publisher = {{Elsevier}}, series = {{Journal of Chromatography A}}, title = {{Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase}}, url = {{http://dx.doi.org/10.1016/0021-9673(94)87016-0}}, doi = {{10.1016/0021-9673(94)87016-0}}, volume = {{664}}, year = {{1994}}, }