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Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid

Tsofliou, Fotini ; Fyfe, Claire L. ; Matheson, Ian ; Jackson, Diane M. ; Horgan, Graham W. ; Wahle, Klaus W. J. ; Ahrén, Bo LU ; Williams, Lynda M. and Sneddon, Alan A. (2009) In Journal of Food Lipids 16(4). p.499-513
Abstract
Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein... (More)
Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P < 0.05) and postprandial total cholesterol levels (P < 0.05). In young lean subjects, CLA/n-3-PUFA reduced postprandial NEFA levels (P < 0.05) whereas in young obese subjects, postprandial total cholesterol and triacylglycerols were lowered (both P < 0.05). Therefore, a dietary combination of CLA together with n-3-PUFA may have favorable effects on plasma lipids in young and older lean men but detrimental effects in older obese men. PRACTICAL APPLICATIONS This study suggests that where individuals consume a combination of both omega-3 polyunsaturated fatty acids and conjugated linoleic acid supplements in order to obtain potential additive beneficial effects of each lipid on adiposity and health, this particular fatty acid combination may have harmful effects on plasma lipid biomarkers of cardiovascular disease in older obese men. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Food Lipids
volume
16
issue
4
pages
499 - 513
publisher
Wiley-Blackwell
external identifiers
  • wos:000272189100008
  • scopus:73449143841
ISSN
1065-7258
DOI
10.1111/j.1745-4522.2009.01162.x
language
English
LU publication?
yes
id
03739efe-ccbb-4258-91b6-9b7f4edee528 (old id 1517682)
date added to LUP
2016-04-01 13:31:21
date last changed
2024-10-10 03:37:54
@article{03739efe-ccbb-4258-91b6-9b7f4edee528,
  abstract     = {{Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P &lt; 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P &lt; 0.05) and postprandial total cholesterol levels (P &lt; 0.05). In young lean subjects, CLA/n-3-PUFA reduced postprandial NEFA levels (P &lt; 0.05) whereas in young obese subjects, postprandial total cholesterol and triacylglycerols were lowered (both P &lt; 0.05). Therefore, a dietary combination of CLA together with n-3-PUFA may have favorable effects on plasma lipids in young and older lean men but detrimental effects in older obese men. PRACTICAL APPLICATIONS This study suggests that where individuals consume a combination of both omega-3 polyunsaturated fatty acids and conjugated linoleic acid supplements in order to obtain potential additive beneficial effects of each lipid on adiposity and health, this particular fatty acid combination may have harmful effects on plasma lipid biomarkers of cardiovascular disease in older obese men.}},
  author       = {{Tsofliou, Fotini and Fyfe, Claire L. and Matheson, Ian and Jackson, Diane M. and Horgan, Graham W. and Wahle, Klaus W. J. and Ahrén, Bo and Williams, Lynda M. and Sneddon, Alan A.}},
  issn         = {{1065-7258}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{499--513}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Food Lipids}},
  title        = {{Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid}},
  url          = {{http://dx.doi.org/10.1111/j.1745-4522.2009.01162.x}},
  doi          = {{10.1111/j.1745-4522.2009.01162.x}},
  volume       = {{16}},
  year         = {{2009}},
}